2014)Studies on the association of BF1/BF2 gene expression patterns with traits of genetic resistance to Marek's disease in chickens, Food and Agricultural Immunology, 25:2, 220-228,The aim was try to clarify the association of BF1 and BF2 gene expression patterns with the traits of genetic resistance to Marek's disease (MD) in chickens. An MD-resistant line and a common line of Xiayan chickens were used in the experiment. The productions of mRNA of BF1 and BF2 and Marek's disease virus (MDV) gene, meq, were quantified by quantitative real-time PCR on different days post-infection (dpi) with virulent MDV in the peripheral blood leukocytes (PBLs). Results indicated that the MDV loads were lower in the MDresistant line compared to the common line. The mRNA levels of BF1 were significantly lower and levels of BF2 higher in the MD-resistant line whereas levels of BF1 were significantly higher and levels of BF2 lower in the common line. The results demonstrated that the expression modes of BF1 and BF2 genes might be related to traits of genetic resistance to MD in the chicken.
By the titrations of the antibody response to the vaccinations of avian influenza (AI) and Newcastle disease (ND), the present study was conducted to evaluate the effects of Marek's disease (MD)-resistant breeding and vaccination against the immunosuppression induced by virulent Marek's disease virus (MDV). The results showed that haemagglutination inhibition (HI) titres to AI and ND in MDV-unchallenged groups were significantly higher than those of MDVchallenged groups (PB0.05), those of the resistant birds were significantly higher than those of the common birds (PB0.05) and those of the herpes virus of turkeys (HVT)-vaccinated birds were significantly higher than those of the HVTunvaccinated birds (PB0.05). The results demonstrated that antibody responses to the vaccinations of AI and ND were significantly suppressed by MDV infection, and MD-resistant breeding and HVT vaccination could significantly increase resistance to the suppression.
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