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There are no significant differences in survival/mortality rates between OLT as de novo therapy and OLT as a rescue therapy for patients with hcc. Pre-OLT hyperbilirubinemia, post-OLT requirement of transfusion, large tumor size and family history of HCC are associated with a poor survival outcome.

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Objective To investigate the clinical value of ultrasound plus magnetic resonance imaging (MRI) for the diagnosis of breast masses and fibroids. Methods Clinical data for 357 patients with breast masses diagnosed at our hospital were analyzed retrospectively. The diagnostic performances were compared between 243 patients who underwent routine ultrasound examinations (control group) and 114 patients who underwent routine ultrasound plus MRI (test group). Results The overall accordance rates of routine ultrasound and routine ultrasound plus MRI for the diagnosis of breast masses, based on postoperative pathological diagnoses, were 70.78% (172/243) and 90.35% (103/114). The addition of MRI significantly improved the overall diagnostic performance of routine ultrasound for breast masses. The diagnostic accordance rate of routine ultrasound for the diagnosis of breast fibroids (fibroadenomas) was 74.12% (63/85 cases) compared with 93.94% (31/33 cases) for routine ultrasound plus MRI. The diagnostic performance of routine ultrasound plus MRI was therefore also significantly higher than routine ultrasound alone for diagnosing breast fibroids. Conclusions Routine ultrasound plus MRI can greatly improve the diagnostic accordance rates for breast masses and fibroadenomas.

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Background: Maffucci syndrome is a rare, nonhereditary congenital mesodermal dysplasia characterized by multiple enchondromas and hemangiomas. It is associated with an increased risk of the development of malignant tumors. We present a case of 45-year-old man with Maffucci syndrome to supplement the clinical manifestations and explore the molecular mechanism of Maffucci syndrome.Results: The patient was underwent amputation surgery to inhibit tumor development and diagnosed as Maffucci syndrome with 1-2 grade giant chondrosarcoma in the left ankle. In addition, the whole exon analysis by Next Generation Sequencing revealed isocitrate dehydrogenase 1 R132C mutation in chondrosarcoma lesions but not in blood DNA. Conclusions: This case report presents the genetic evidence for the inclusion of chondrosarcoma among tumors characterizing Maffucci syndrome. Consequently, it is suggested that patients with Maffucci syndrome should be followed up more actively to exclude neoplasms due to IDH1 R132C somatic mutation.

Background This study aims to determine the prediction performance of a machine learning-based clinical model for cervical lymph node metastasis (CLNM) in micropapillary thyroid carcinoma (MPTC) with ultrasound (US).Methods Patients with MPTC who underwent total or hemithyroidectomy with unilateral or bilateral prophylactic central neck dissection were included (n = 692). Nodal status was pathologically determined. Clinical and US features and thyroid function markers were extracted to build a random forest model. A nomogram with the significant predictive risk factors from multivariable logistic regression analysis was built to visualize hazard rates. Finally, the predictive performances of the models were compared.Results Overall, 332 patients (47.98%) had CLNM. In multiple logistic regression, the strong predictive risk factors for CLNM were younger age, larger anteroposterior diameter, lower anteroposterior/transverse diameter (A/T) ratio, and higher thyroglobulin (TG) concentration (P < 0.05). The random forest and nomogram models showed good predictive performance with the area under the curves (AUCs) of 0.836 and 0.780, respectively, which were significantly higher than those without A/T ratio in the models (AUCs: 0.807 vs. 0.722, all P < 0.05). The AUC of the A/T ratio as a single feature for predicting CLNM was 0.744, while A/T ratio (≤ 0.828) combined with anteroposterior diameter (≥ 10 mm) yielded a higher AUC of 0.754 for predicting CLNM.Conclusions The machine learning-based clinical model with US had a good predictive performance for CLNM in MPTC patients. This clinical model may facilitate surgical decision-making for MPTC, especially regarding whether cervical lymph node dissection is warranted.

S o n g r a m s o f 1 2 8 c h i n e s e f e t u s e s s c a n n e d between 16-20 week' gestational age, with l a s t m e n s t r u a l p e r i o d a n d a v e r a g e s o n og r a p h i c a g e c o r r e s p o n d i n g b y ± 1 0 d a y s , w e r e e v a l u a t e d r e t r o s p e c t i v e l y . T h e f e t a l f e m u r l e n g h t w a s m e a s u r e d l o n g i t u d i n a l l y u s i n g a l i n e a r p h a s e d a r r a y t r a n s d u c e r . T h e o b s e r v e d s p o n d i n g d a t a i n H a d l o c k ' s c h a r t , w h i c h i s based on a white middle class population. Res u l t s i n d i c a t e d t h a t t h e c h i n e s e f e m u r l e n g h t w a s s h o r t e r t h a n t h e h a d l o c k v a l u e s b y o . 5 6 m m . T h e a n a l y s i s o f v a r i a n c e r e v e a l e d t h a t this differency. Although the findings were statisf o r a n a d j u s t m e n t t o t h e H a d l o c k c h a r t , a sThe ultrasound measurement of the fetal femur length is considered one of the most accurate biometric measurements in determining gestational age.l I However, the femur length charts most commonly used are Hadlock's tables, which were created based on white middle class populations.2 Because of the observation and general acceptance of various height differences found between the Chinese population and the white population, a retrospective study was initiated to determine if these differences are evident in utero and if they affect accepted measurements used for prediction of gestational age.