Objectives To investigate the potential of dual-energy computed tomography (DECT) parameters in identifying metastatic cervical lymph nodes in oral squamous cell carcinoma (OSCC) patients and to explore the relationships between DECT and pathological features. Methods Clinical and DECT data were collected from patients who underwent radical resection of OSCC and cervical lymph node dissection between November 2019 and June 2021. Microvascular density was assessed using the Weidner counting method. The electron density (ED) and effective atomic number (Zeff) in non - contrast phase and iodine concentration (IC), normalized IC, slope of the energy spectrum curve (λHU), and dual-energy index (DEI) in parenchymal phase were compared between metastatic and non - metastatic lymph nodes. Student’s t-test, Pearson’s rank correlation, and receiver operating characteristic curves were performed. Results The inclusion criteria were met in 399 lymph nodes from 103 patients. Metastatic nodes (n = 158) displayed significantly decreased ED, IC, normalized IC, λHU, and DEI values compared with non-metastatic nodes (n = 241) (all p < 0.01). Strong correlations were found between IC (r = 0.776), normalized IC (r = 0.779), λHU (r = 0.738), DEI (r = 0.734), and microvascular density. Area under the curve (AUC) for normalized IC performed the highest (0.875) in diagnosing metastatic nodes. When combined with the width of nodes, AUC increased to 0.918. Conclusion DECT parameters IC, normalized IC, λHU, and DEI reflect pathologic changes in lymph nodes to a certain extent, and aid for detection of metastatic cervical lymph nodes from OSCC. Key Points • Electron density, iodine concentration, normalized iodine concentration, λHU, and dual-energy index values showed significant differences between metastatic and non-metastatic nodes. • Strong correlations were found between iodine concentration, normalized iodine concentration, slope of the spectral Hounsfield unit curve, dual-energy index, and microvascular density. • DECT qualitative parameters reflect the pathologic changes in lymph nodes to a certain extent, and aid for the detection of metastatic cervical lymph nodes from oral squamous cell carcinoma.
Objective To explore the feasibility of measuring the volume of Meckel’s cave by MRI before operation and its value in guiding percutaneous balloon compression (PBC) of trigeminal nerve (TN). Methods The preoperative MRI and operative data of 31 patients, who underwent PBC of TN, were analyzed retrospectively. Axial scanning was performed using T2-weighted three-dimensional high-resolution MRI, and then coronal and sagittal images were reconstructed. Volumes of Meckel’s cave were measured by two radiologists, and their consistence was assessed using intraclass correlation coefficient (ICC). Pearson and Spearman analyses were used to assess the correlations of the volumes of Meckel’s cave among coronal, sagittal, and axial MRI images, and between that measured by MRI and the filling volume of operative balloon (OPB), respectively. Bland-Altman plot was used to assess their agreements. Results There was high consistency in volumes of Meckel’s cave between the two radiologists with ICC from 0.921 to 0.962. High correlations and good agreements in volumes of Meckel’s cave were obtained from the three orientations, with Pearson coefficients and differences of 0.96 and 0.01 ml (coronal vs sagittal), 0.95 and 0.01 ml (coronal vs axial), and 0.95 and 0.00 ml (sagittal vs axial), respectively. The moderate correlation and good agreements were also obtained between MRI and OPB volume (ρ = 0.448, p < 0.05; difference, 0.02 ml). Conclusion It is feasible to measure the volume of Meckel’s cave by MRI before operation, and it is of guiding significance for the individual selection of balloon filling volume in PBC of TN. Advances in knowledge This is the first study to investigate the relationships between the three- dimensional high resolution MRI images and the clinic volume of Meckel’s cave. The high-resolution MRI method can help guide PBC of TN.
Ciprofloxacin is widely used in general infected population, including patients with aortic dissection. Ciprofloxacin-mediated neurotoxicity has been observed in few reports, and some studies found ciprofloxacin may increase the incidence of aortic dissection or aortic aneurysm rupture. We report here a case of ciprofloxacin-induced acute psychosis after Sun’s total arch replacement and cardiopulmonary resuscitation. Based on the published literature and FDA hypothesis, we suggest that ciprofloxacin should be used cautiously in patients after aortic dissection surgery in the risk of drug-induced psychosis and residual dilated aortic rupture.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.