ye? omem r a n % ! cofftis. we ieter h e 3 tfe incfience anA maniestations of CD and C in 3 ?~p) of children with suspectWe have used SPA adsorption t o remove maternal IgG from cord ed acute or chronic AID (Gp ffou%ildren with chronic diarrhea o r neonatal sera t o f a c i l i t a t e the diagnosis o f congenital g:;o?&~'cf~~it~~p$zj~ therapy9(Gp 11) and control children with.infection. TO evaluate the c l i n i c a l usefulness o f t h i s procedure, sera sent for "TORCH" serology t h a t were r u b e l l a HI (RHI) o r Number (n) Mean Age Ma1e:Female +C.D. culture C of Patients (E.) toxoplasmosis FA (TFA) p o s i t i v e were retested a f t e r SPA adsorpn tested n..tested tion. RHI o r TFA was repeated a f t e r 4 months o f age. confirmed by rectal biops without pseudomembranes on proctosigt i o n have been retested a t 24 months. The i n f a n t thought t o have moidoscop A11 7 atienfs in G I became asymptomatic within 6 congenital r u b e l l a had a RHI o f 1:64; another w i t h m u l t i p l e weeks of Ziscontinugng antimicrogial therapy exce t 1 atient who received oral vancomycin (V) and became asymp!omat$c during anomalies was 1:16; the r e s t were <1:8. From Jan 1979-Nov 1980, V thera y but diarrhea recurred after V theraav with stool cul-10 of 110 sera sent f o r TORCH serology were TFA p o s i t i v e . A f t e r ture + tor CD and C for u to 6 months Children may become SPA adsorption only 1 specimen remained p o s i t i v e and t h i s c h i l d chronic carriers f CD. tRe re ence oi D and C can be u ed to distinguish acute9chrobic coPitas relates to antimicrobiaf therhad congenital toxoplasmosis. We conclude t h a t i n f a n t s RHI orTFA apy from other causes of colitis in children.negative a f t e r SPA adsorption are u n l i k e l y t o be infected w i t h these agents. Children w i t h residual antibody should be evaluated further. Using t h i s simple technique, p o s i t i v e serology was shown t o be unrelated t o i n t r a u t e r i n e i n f e c t i o n f o r 85% o f RHI p o s i t i v e sera and 90% o f TFA p o s i t i v e sera. University o f Utah College o f Medicine, S a l t Lake City, Utah. The incidence o f n a t a l l y acquired Herpes simplex i n f e c t i o n s NEUTRALIZATION OF HERPES SIMPLEX VIRUS BY ANTIBODY GRANULOCYTE TRANSFUSIONS (GT) INCREASE SURVIVAL INThe m o r t a l i t y o f septic i n f a n t s approaches 80% i f they ex-(HSI) has been estimated t o be 117500 b i r t h s , despite the f a c t h i b i t neutropenia and depletion of the marrow neutrophil stora e t h a t r a t e s o f asymptomatic shedding by pregnant women have been pool ( % PMN + bands + metas/1000 marrow c e l l s ) (J. Peds., 19817. shown t o be as high as 11154. To investigate mechanisms whichWe postulated t h a t GT might decrease m o r t a l i t y i n these i n f a n t s may explain the lower than expected incidence o f c l i n i c a l i n f e cand tested t h i s hypothesis i n an animal model and c l i n i c a l study. t i o n , amniotic f l u i d (AF) obtained during gestation and amnio...
This report describes two cousins with Wilms' tumor and mucin detected in the sera with rapidly fatal courses. A review of the literature reveals five additional reported cases of Wilms' tumor where mucin was observed in the sera. The patients in this report are similar to those previously reported in that all had metastatic disease at diagnosis, and four of five died within one year of diagnosis. Both the extent of disease at diagnosis at the poor response to therapy in these two cases, and those from the literature suggest that evidence of mucin production may indicate poor prognosis in Wilms' tumor. In addition, evidence is reviewed that mucin itself may contribute to a rapid tumor growth and metastases. The genetics of Wilms' tumor and familial nature of these cases is also discussed.
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