Disseminated Herpesvirus hominis infection in a child with acute leukemia

Faden, Howard; Bybee, Blair; Overall, James C.; Lahey, M. Eugene

doi:10.1016/s0022-3476(77)80566-0

Cited by 21 publications

(1 citation statement)

References 12 publications

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“…Sometimes herpes in immunocompromised patients becomes an overwhelming generalised infection. This has been reported in children with leukaemia (Ruiz-Palacios et al, 1977;Faden et al, 1977) in whom haemorrhage and necrosis affecting liver, adrenals, gastrointestinal tract, lungs, and brain were found at postmortem examination (Ruiz-Palacios et al, 1977). Fatal disseminated herpes has been described in a large series of severely malnourished children in South Africa (Becker et al, 1963;Kipps et al, 1967), which suggests that malnourishment-and kwashiorkor in particular-enhances susceptibility to this form of herpes.…”

Section: Infection In Immunocompromised Patientsmentioning

confidence: 91%

Herpesviruses.

Timbury¹,

Edmond²

1979

J Clin Pathol

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Section: Infection In Immunocompromised Patientsmentioning

confidence: 91%

Herpesviruses.

Timbury¹,

Edmond²

1979

J Clin Pathol

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Fatal Disseminated Herpes Simplex Virus Infection in a Healthy Child

Moedy¹,

Lerman²,

White³

1981

Arch Pediatr Adolesc Med

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Infections in children with malignant disease in Argentina

Lopez¹,

Fernándezperona²,

Rocco³

et al. 1981

Cancer

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During six-month period, 102 consecutive episodes of fever in 68 children (ranging from 1 month to 14 years of age) with malignant diseases were prospectively evaluated. Sixty-five had acute lymphoblastic leukemia, nine had acute myeloblastic leukemia, nine had malignant lymphoma (four Hodgkin and five non-Hodgkin), five had chronic myeloid leukemia, four had rhabdomyosarcoma, three had CNS tumors, two had neuroblastoma, one had Wilms, and four had other malignant tumors. Forty cases (39.2%) showed severe neutropenia (500 neutrophil/m3) during the episode. S. aureus, E. coli, and S. pyogenes were in 53% of the 75 microbiologic isolates. Twenty-two percent of the viral studies were positive. Mycologic studies were all negative, except one case with C. Albicans. Pneumonia (33 cases), cellulitis (15 cases), pharyngitis (12 cases), and varicella (11 cases) were the most common final diagnosis. Seventy-one percent of the episodes were etiologically documented (by bacterial isolate, characteristic serology, and/or typical clinic picture); 19% of the febrile episodes were probable infections, and 10% were fever of uncertain cause. Ninety percent of the cases responded well to therapy, and mortality of this series was 7%. Gentamicin, Carbenicillin, and Methicilin were the more common antibiotics employed. We conclude that in our population 1) infection is a frequent cause of morbidity in children with malignant diseases; 2) the most common cause of the febrile episodes is bacterial infection; 3) S. aureus, E. coli and S. pyrogenes are the most frequent bacterial isolates, and P. aeruginosa is infrequent; 4)viral infections are relatively frequent in this group of children; and 5) with adequate management, the mortality is low.

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Disseminated Herpesvirus hominis infection in a child with acute leukemia

Cited by 21 publications

References 12 publications

Herpesviruses.

Herpesviruses.

Fatal Disseminated Herpes Simplex Virus Infection in a Healthy Child

Infections in children with malignant disease in Argentina

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