The plague is an infectious bacterial disease having a high fatality rate without treatment. It has occurred in three huge pandemics since the 6th century with millions of deaths and numerous smaller epidemics and sporadic cases. Referring to specific clinical symptoms of pulmonary plague the disease became known as the Black Death. This pandemic probably originated in central Asia and began spreading westward along major trade routes. Upon the arrival in the eastern Mediterranean the disease quickly spread especially by sea traffic to Italy, Greece and France and later throughout Europe by land. Until the 18th century many European cities were frequently affected by other great plague epidemics. The worldwide spread of the third pandemic began when the plague reached Hong Kong and Canton in the year 1894. The gram-negative coccobacillus now designated as Yersinia pestis has been discovered as the causative agent of plague in this Hong Kong outbreak. In the following years the role of rats and fleas and their detailed role in the transmission of plague has been discovered and experimentally verified. Today the plague is still endemic in many countries of the world.

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Lead is known to have numerous adverse effects especially to infants and children. The intake of lead through drinking water is commonly due to metal corrosion in the peripheral water distribution system, especially the user's plumbing. The aim of this project was to assess the present state of drinking water contamination with lead in Lower Saxony and to promote replacement of lead pipes. For this purpose a project was initiated comprising three parts. First, a free examination of drinking water was offered in cooperation with local public health departments for private households with young women and families with children living in buildings constructed before 1974. Participants were asked to collect a cold tap water sample in their household after nocturnal stagnation and to complete a questionnaire. The collected samples were analysed by atomic absorption spectrometry for their lead concentration. Second, data from local public health departments on results of lead measurements, especially in buildings for the public, were collected and analysed. Finally a working group 'lead replacement' was initiated. In the project in total 2436 tap water samples from households were collected. Of these, 6.49% had lead concentrations exceeding 10 microg/l (recommended limit of the World Health Organization) and 2.79% had concentrations above the limit of the German drinking water ordinance (25 microg/l). There were remarkable regional differences in the frequency of tap water contamination. Multi-family houses were more frequently affected than single- and double-family houses.

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Outbreaks of Legionnaire 's disease present a public health challenge especially because fatal outcomes still remain frequent. The aim of this study was to describe the abundance and epidemiology of Legionellaceae in the human-made environment. Water was sampled from hotwater taps in private and public buildings across the area of Go$ ttingen, Germany, including distant suburbs. Following isolation, we used polymerase chain reaction in order to generate strain specific banding profiles of legionella isolates. In total, 70 buildings were examined. Of these 18 (26 %) had the bacterium in at least one water sample. Legionella pneumophila serogroups 1, 4, 5 and 6 could be identified in the water samples. Most of the buildings were colonized solely by one distinct strain, as proven by PCR. In three cases equal patterns were found in separate buildings. There were two buildings in this study where isolates with different serogroups were found at the same time.

In the project in total 2,901 tap water samples from households were collected between the years 2005 and 2007. Of these, 7.5% had lead concentrations exceeding 10 microg/L (recommended limit of the World Health Organisation) and 3.3% had concentrations above the limit of the German drinking water ordinance (25 microg/L). There were remarkable regional differences in the frequency of tap water contamination. Multi-family houses were more frequently affected than single and double family houses. Additional data were collected in a preceding study in southern Lower Saxony. Of the 1 434 stagnation samples, 3.1% had lead concentrations greater than 10 microg/L and 0.6% had concentrations above the former limit of the German drinking water regulations of 40 microg/L.