We report on the new polycrystalline exchange bias system MnN/CoFe, which shows exchange bias of up to 1800 Oe at room temperature with a coercive field around 600 Oe. The room temperature values of the interfacial exchange energy and the effective uniaxial anisotropy are estimated to be J eff = 0.41 mJ/m 2 and K eff = 37 kJ / m 3 . The thermal stability was found to be tunable by controlling the nitrogen content of the MnN. The maximum blocking temperature exceeds 325• C, however the median blocking temperature in the limit of thick MnN is 160• C. Good oxidation stability through self-passivation was observed, enabling the use of MnN in lithographically defined microstructures. As a proof-of-principle we demonstrate a simple GMR stack exchange biased with MnN, which shows clear separation between parallel and antiparallel magnetic states. These properties come along with a surprisingly simple manufacturing process for the MnN films.
The collective “single‐file” motion of water molecules through natural and artificial nanoconduits inspires the development of high‐performance membranes for water separation. However, a material that contains a large number of pores combining rapid water flow with superior ion rejection is still highly desirable. Here, a 1.2 nm thick carbon nanomembrane (CNM) made from cross‐linking of terphenylthiol (TPT) self‐assembled monolayers is reported to possess these properties. Utilizing their extremely high pore density of 1 sub‐nm channel nm−2, TPT CNMs let water molecules rapidly pass, while the translocation of ions, including protons, is efficiently hindered. Their membrane resistance reaches ≈104 Ω cm2 in 1 m Cl− solutions, comparable to lipid bilayers of a cell membrane. Consequently, a single CNM channel yields an ≈108 higher resistance than pores in lipid membrane channels and carbon nanotubes. The ultrahigh ionic exclusion by CNMs is likely dominated by a steric hindrance mechanism, coupled with electrostatic repulsion and entrance effects. The operation of TPT CNM membrane composites in forward osmosis is also demonstrated. These observations highlight the potential of utilizing CNMs for water purification and opens up a simple avenue to creating 2D membranes through molecular self‐assembly for highly selective and fast separations.
Scaffold materials for bone regeneration are crucial for supporting endogenous healing after accidents, infections, or tumor resection. Although beneficial impacts of microtopological or nanotopological cues in scaffold topography are commonly acknowledged, less consideration is given to the interplay between the microscale and nanoscale. Here, micropores with a 60.66 ± 24.48 µm diameter ordered by closely packed collagen fibers are identified in pre-wetted Spongostan, a clinically-approved collagen sponge. On a nanoscale level, a corrugated surface of the collagen sponge is observable, leading to the presence of 32.97 ± 1.41 nm pores. This distinct micro-and nanotopography is shown to be solely sufficient for guiding osteogenic differentiation of human stem cells in vitro. Transplantation of Spongostan into a critical-size calvarial rat bone defect further leads to fast regeneration of the lesion. However, masking the micro-and nanotopographical cues using SiO 2 nanoparticles prevents bone regeneration in vivo. Therefore, we demonstrate that the identified micropores allow migration of stem cells, which are further driven towards osteogenic differentiation by scaffold nanotopography. The present findings emphasize the necessity of considering both microand nanotopographical cues to guide intramembranous ossification, and might provide an optimal cell-and growth-factor-free scaffold for bone regeneration in clinical settings. Cells 2020, 9, 654 2 of 17 Cells 2020, 9, 654 3 of 17 Materials and Methods Study DesignThe study design is depicted in Figure 1. Briefly, micropores and nanopores were identified in Spongostan, followed by assessment of their osteoinductive capacity in vitro. For investigation of bone regeneration in vivo, Spongostan was transplanted into critical-size calvarial defects. Next to an empty control, we applied sole collagen fibers (control lacking the microtopography of Spongostan) and Spongostan masked with nanoparticles (control lacking nano-and microtopography).Cells 2020, 9, x 3 of 18 Study DesignThe study design is depicted in Figure 1. Briefly, micropores and nanopores were identified in Spongostan, followed by assessment of their osteoinductive capacity in vitro. For investigation of bone regeneration in vivo, Spongostan was transplanted into critical-size calvarial defects. Next to an empty control, we applied sole collagen fibers (control lacking the microtopography of Spongostan) and Spongostan masked with nanoparticles (control lacking nano-and microtopography).
Topological crystalline insulators represent a new state of matter, in which the electronic transport is governed by mirror-symmetry protected Dirac surface states. Due to the helical spin-polarization of these surface states, the proximity of topological crystalline matter to a nearby superconductor is predicted to induce unconventional superconductivity and, thus, to host Majorana physics. We report on the preparation and characterization of Nb-based superconducting quantum interference devices patterned on top of topological crystalline insulator SnTe thin films. The SnTe films show weak anti-localization, and the weak links of the superconducting quantum interference devices (SQUID) exhibit fully gapped proximity-induced superconductivity. Both properties give a coinciding coherence length of 120 nm. The SQUID oscillations induced by a magnetic field show 2π periodicity, possibly dominated by the bulk conductivity.
Chronic rhinosinusitis (CRS) is marked by an inflamed mucosa of sinuses and is accompanied by a significantly reduced quality of live. Since no guidelines for the treatment of CRS are available, long lasting clinical histories with health care costs adding up to dozens of billion $ annually are caused by CRS. The progression of CRS is often induced by bacterial infections and/or a shift in microbiome as well as biofilm formation. The exact microbiome alterations are still unclear and the impenetrable biofilm renders the treatment with common antibiotics ineffective. This study focuses on characterizing the microbiome changes in CRS and investigating the inhibition of biofilm growth by 1,8-Cineol, a small, non-polar and hence biofilm penetrating molecule with known antimicrobial potential. We performed MALDI-TOF MS based characterization of the microbiomes of healthy individuals and CRS patients (n = 50). The microbiome in our test group was shifted to pathogens (Staphylococcus aureus, Escherichia coli, and Moraxella catarrhalis). In contrast to published studies, solely based on cell culture techniques, we could not verify the abundance of Pseudomonas aeruginosa in CRS. The inhibition of bacterial proliferation and biofilm growth by 1,8-Cineol was measured for these three pathogens. Interestingly, S. aureus, the most prominent germ in CRS, showed a biofilm inhibition not simply correlated to its inhibition of proliferation. RT-qPCR confirmed that this was due to the downregulations of major key players in biofilm generation (agrA, SarA and σB) by 1,8-Cineol. Furthermore we verified this high biofilm inhibition potential in a model host system consisting out of S. aureus biofilm grown on mature respiratory epithelium. A second host model, comprising organotypic slices, was utilized to investigate the reaction of the innate immune system present in the nasal mucosa upon biofilm formation and treatment with 1,8-Cineol. Interestingly Staphylococcus epidermidis, the cause of very common catheter infections, possesses a biofilm generation pathway very similar to S. aureus and might be treatable in a similar fashion. The two presented in vitro model systems might be transferred to combinations of every biofilm forming bacterial with most kind of epithelium and mucosa.
Thermally stabilized and subsequently carbonized nanofibers are a promising material for many technical applications in fields such as tissue engineering or energy storage. They can be obtained from a variety of different polymer precursors via electrospinning. While some methods have been tested for post-carbonization doping of nanofibers with the desired ingredients, very little is known about carbonization of blend nanofibers from two or more polymeric precursors. In this paper, we report on the preparation, thermal treatment and resulting properties of poly(acrylonitrile) (PAN)/poly(vinylidene fluoride) (PVDF) blend nanofibers produced by wire-based electrospinning of binary polymer solutions. Using a wide variety of spectroscopic, microscopic and thermal characterization methods, the chemical and morphological transition during oxidative stabilization (280 °C) and incipient carbonization (500 °C) was thoroughly investigated. Both PAN and PVDF precursor polymers were detected and analyzed qualitatively and quantitatively during all stages of thermal treatment. Compared to pure PAN nanofibers, the blend nanofibers showed increased fiber diameters, strong reduction of undesired morphological changes during oxidative stabilization and increased conductivity after carbonization.
We investigated the influence of doping antiferromagnetic MnN in polycrystalline MnN/CoFe exchange bias systems, showing high exchange bias of up to 1800 Oe at room temperature. The thermal stability of those systems is limited by nitrogen diffusion that occurs during annealing processes. In order to improve the thermal stability, defect energies of elements throughout the periodic table substituting Mn were calculated via density functional theory. Elements calculated to have negative defect energies bind nitrogen stronger to the lattice and could be able to prevent diffusion. We prepared exchange bias stacks with doping concentrations of a few percent by (reactive) co-sputtering, testing doping elements with defect energies ranging from highly negative to slightly positive. We show that doping with elements calculated to have negative defect energies indeed improves the thermal stability. Y doped MnN layers with doping concentrations below 2% result in systems that show exchange bias fields higher than 1000 Oe for annealing temperatures up to 485 • C.In spinelectronics, the exchange bias effect 1-5 is used to pin a ferromagnetic electrode to an antiferromagnetic layer. This is crucial in GMR or TMR stacks to allow for distinct stable resistance states 6 . For several years, the search for new antiferromagnetic materials for exchange bias has been going on in order to find rare-earth free alternatives for commonly used MnIr 7 or MnPt 8,9 . For integration into spinelectronic devices, the antiferromagnet should be easy to prepare, generate exchange bias fields that are clearly higher than corresponding coercive fields and be thermally stable at typical device operation temperatures. As we recently reported 10-12 , antiferromagnetic MnN is a very promising candidate. MnN crystallizes in the Θ−phase of the Mn-N phase diagram 13 , a tetragonal variant of the NaCl structure with a = b = 4.256Å and c = 4.189Å at room temperature 14 . The exact lattice constants depend on the nitrogen content in the lattice. With increasing nitrogen content, increasing lattice constants are observed 14,15 . Optimized polycrystalline MnN/CoFe bilayer systems show exchange bias of up to 1800 Oe at room temperature with an effective interfacial exchange energy of J eff = 0.41 mJ/m 2 and an effective uniaxial anisotropy constant of K eff = 37 kJ/m 3 10 . They yield ratios of H eb /H c significantly larger than one and are easy to prepare with sputter deposition at room temperature, satisfying earlier mentioned requirements for integration into spintronic devices. The Néel temperature of MnN is around 660 K 16 and MnN/CoFe systems show a median blocking temperature of 160 • C 10 . However, nitrogen diffusion at high temperatures, respectively long annealing times, limits the thermal stability of the system. In the course of our previous investigations 10 we already found that preparing MnN with a higher nitrogen concentration can slightly increase the thermal stability but at the same time lowers the exchange bias. In the present article, w...
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