In the design of membrane distillation systems, the effect of different heat transfer coefficient models on the transmembrane flux seems to have been overlooked thus far. Interestingly, the range of discrepancy in the results of the transmembrane flux is wide, especially in the laminar flow region, where MD is often operated. This can be inferred by studying the design and parameters of the direct contact membrane distillation system. In this study, the physical and physiochemical properties that affect the design of MD are comprehensively reviewed, and based on the reviewed parameters, an MD design algorithm is developed. In addition, a cost analysis of the designed MD process for low-grade-energy fluids is conducted. As a result, a total unit product cost of USD 1.59/m3, 2.69/m3, and 15.36/m3 are obtained for the feed velocities of 0.25, 1 and 2.5 m/s, respectively. Among the design parameters, the membrane thickness and velocity are found to be the most influential.