A 3-MeOsalophen-ligand based Co2 complex underwent controlled pyrolysis tracked by TG-MS, and can be used as an efficient OER electrocatalyst with a Co/CoOx@NC nanostructure.
Main observation and conclusion
Exploring pyrolysis process is an efficient way to study the relationship between molecular level of the precursor structure and electrocatalytic functional materials in practice. Here, the unique semi‐enclosed sector structure of Salophen ligands with highly symmetric N, N, O, O mode was introduced to construct binuclear Co complex [Co2(salophen)(Cl)2(C2H3N)] (compound 1), which provides preliminary theoretical basis for the efficient coreshell structure electrocatalysts obtained by pyrolysis regulation. Moreover, we adopted TG‐MS to real‐time track the pyrolysis process from precursors of binuclear Co complexes with Salophen ligand to efficient catalytic materials with core‐shell nanostructures. As expected, the 1‐600 sample achieves ultra‐low overpotential of 256 mV at 10 mA·cm–2 and high catalytic stability within 10 h in 1 mol/L KOH solution. This work highlights salophen‐ligated complex as excellent precursor material system for the analysis of pyrolysis evolution process, and provides an opportunity for targeted preparation of efficient oxygen evolution reaction (OER) nanocatalysts.
RNA molecules have been found to play important roles in DNA double‐strand break (DSB) repair, but the exact underlying mechanism remains unclear. Here, we aimed to clarify the function of RNase L, an important ribonuclease in the immune system of vertebrates, in DSB repair. Knockdown of RNase L reduces cell survival after induction of DSBs by ionizing radiation or camptothecin and causes a significant decrease in DSB repair, as evidenced by an increase in the extent of phosphorylation of histone H2AX on Ser139 (γH2AX) and γH2AX nuclear foci formation. Thus, our findings indicate that RNase L interacts with the core factors involved in DNA end joining, such as XRCC4 and Lig4, and facilitates DSB repair through the nonhomologous end‐joining pathway.
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