has become a global public health problem with widespread rapid increase. Resulting in high morbidity, disability, and mortality, CRE brings considerable challenges to clinical treatment and severe burdens to society (2,3). It is much easier for the elderly, immunocompromised and critically ill patients to infect CRE. The mortality rate is between 40% and 50% for severe patients with CRE bloodstream infections (4). In order to effectively decrease case-fatality rates among patients with the infections owing to CRE infection, combination antibiotic schemes, including colistin
Results (1) Most of the people have a moderate maximal potential platelet activity except 7.1% with very low level and 14.3% with very high level potential platelet activity. (2) Through residual platelet activity detecting, it can be seen that patients who are sensitive in ADP pathway are not necessarily sensitive in AA pathway, and vice-versa. (3) The frequency percent from clopidogrel is 22.0% in inhibition rate of platelet activation less than 50% group, 18.8% in that more than 90% group. But that from aspirin is 14.6% and 26.5%, p¼0.0778 between the two pathways. Conclusions Potential platelet activities are not same in different patients; Residual platelet activities are also different; Even for the same patient, the platelet inhibition ability derived from Aspirin is different from that from Clopidegrel. These individual differences in platelet activity further prove the necessity for case by case analysis and remedy adjustment. Objective The study tested the antioxidant probucol for endothelial dependent vasodilation reaction in the patients of ACS after received therapy. Methods 51 ACS patients were divided randomly into a probucol treatment group (p) and a routine treatment group (C). Oxidised low-density lipoprotein (ox-LDL) was measured in peripheral blood by Sandwich ELISE method. The brachial arterial hyperaemiainduced flow mediated dilation (FMD) and sublingual nitroglycerin (NTG) mediated vasodilation were measured by high resolution ultrasound. These variables were analysed after received probucol 3 months. Results The level of FMD with probucol treatment group was significantly increased after 3 months compared to pretreamented (p<0.05), while the level of ox-LDL in peripheral blood in ACS patients was markedly diseased (p<0.01). The FMD with probucol treatment group was significantly increased compared to ACS routine treatment group (p<0.05), while the level of ox-LDL was markedly desaesed (p<0.01). The linear correlation analysis showed that plasma ox-LDL was a negative correlation with FMD in after treatmented patients by probucol with ACS (r¼À0.517, p<0.001). Conclusions It was important that vascular endothelial function and endothelial dependent vasodilation reaction may be improved in the ACS patients of after the antioxidant probucol therapy. Hydrogen sulfide (H 2 S) is found to be the third endogenous gaseous transmitter and plays an important role in many systems of organism. In cardiovascular system, H 2 S is produced endogenously by cystathionine gamma-lyase (CSE). The CSE/H 2 S system executes the physiological function of vasorelaxation, inhibition of vascular remodelling and cardioprotection. It is also concerned with variety of cardiovascular diseases such as hypertension and pulmonary hypertension. These results suggest that H2S may be a novel cardiovascular functional regulator. And, at another hand, EPCs incorporate into the process of injured carotid reendothelialisation. EPCs transplantation induces an increase in the circulating EPCs, accelerates the process of endothelia...
Acute myocardial infarction is mostly caused by coronary atherosclerotic stenosis or thrombosis. Myocardial infarction directly caused by left fascicular pacing is rarely reported.We reported a 60-year-old male patient who accepted left bundle branch pacing (LBBP). After operation, this patient experienced acute myocardial infarction (AMI), Adams-stokes syndrome and was treated successfully at last.
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