Challenges in the nursing care of intracranial carbapenem-resistant Escherichia coli infection after severe traumatic brain injury: a case report

Wang, Ping; Gao, Bingbing; Wang, Ming; Sheng, Qinsong; Tu, Mingmin

doi:10.21037/apm-20-1264

Cited by 2 publications

(2 citation statements)

References 11 publications

(11 reference statements)

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“…By adjusting the height of the drainage bag at any time to control the drainage flow rate, it was controlled at 10-15ml per hour [9] . There was no significant difference in average drainage speed, drainage time, and total drainage flow rate.Compared with the conventional drainage mode, the fluctuation of drainage speed was small, ensuring a slow and uniform flow rate, and avoiding the formation of a large pressure gradient due to excessive drainage flow rate per unit time, Therefore, the incidence of complications was lower, which is consistent with the research results of scholars such as Zhou Xiaoxiao [10][11][12] . In addition, this article compared the cerebrospinal fluid indicators and intracranial pressure before and after drainage in two groups.…”

Section: Discussionsupporting

confidence: 81%

Application of lumbar drainage based on flow control in patients with intracranial infection after craniocerebral surgery

2024

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To explore the application effect of lumbar cistern based on flow control in patients with intracranial infection, 40 patients with postoperative intracranial infection and lumbar cistern surgery in our hospital from January 2021 to December 2023 were selected as the study subjects. The random number table method was used to divide the participants into an observation group and a control group. The control group received routine drainage, while the observation group received flow control. Both groups were intervened until the end of drainage, then the drainage situation, incidence of complications, and cerebrospinal fluid characteristics were compared. There was no statistically significant difference in drainage speed, drainage time, and total drainage volume between the two groups. The observation group showed lower white blood cell count, intracranial pressure, protein and glucose quantification, and overall incidence of complications compared to before drainage, and was superior to the control group. The lumbar cistern based on flow control is more stable in patients with intracranial infection after craniotomy, and has positive significance in improving cerebrospinal fluid indicators, reducing complications, and patient prognosis.

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Section: Discussionsupporting

confidence: 81%

Application of lumbar drainage based on flow control in patients with intracranial infection after craniocerebral surgery

2024

medsc

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“…It is reported that approximately 10 million people suffer TBI annually, which places a significant heavy load on public health (1,2). TBI negatively impacts individuals' life quality and brings a heavy family and societal burden (3). Because of the immediate and delayed effects of injury, the pathology of TBI is not merely complex, but is heterogeneous (4).…”

Section: Introductionmentioning

confidence: 99%

Identification of candidate genes and pathways in dexmedetomidine-induced neuroprotection in rats using RNA sequencing and bioinformatics analysis

Yang

et al. 2021

Ann Palliat Med

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Background: Traumatic brain injury (TBI) is a major cause of disability worldwide, without definitive and effective intervention. Dexmedetomidine (DEX) has a neuroprotective effect against TBI; however, the detailed mechanism underlying this effect remains unclear.Methods: Ten male Sprague Dawley rats were used to establish a TBI model. The rats were randomly divided into two groups: the TBI group (TBI, control group) and the DEX treatment group (DEX). The next day, the neurological function of the rats were evaluated by the modified neurological severity score (mNSS). Then, the rats were sacrificed, and RNA sequencing was performed to identify differentially expressed messenger RNAs (mRNAs) and microRNAs (miRNAs) in brain tissue samples. Additionally, we performed a bioinformatics analysis to explore the candidate genes and pathways that might play important roles in DEX-induced neuroprotection. The most significantly differentially expressed miRNAs and possible hub genes were validated by quantitate reverse transcription-polymerase chain reaction (qRT-PCR) using more samples.Results: In the DEX group, 517 mRNAs (352 up-regulated and 165 down-regulated) and 35 miRNAs (18 up-regulated and 17 down-regulated) were differentially expressed compared to the TBI group. Gene Ontology analysis revealed the up-regulated mRNAs to be significantly enriched in microtubule-based movement or processes, microtubule and tubulin binding. Kyoto Encyclopedia of Genes and Genomes analysis showed that these up-regulated mRNAs were significantly enriched in the B-cell receptor signaling pathway as well as the cell cycle pathway. Also, Lyn and Cdk1 were found to be associated with the B-cell receptor signaling and cell cycle pathways, respectively. Furthermore, the down-regulated miRNAs were significantly enriched in cellular components, although no significant Gene Ontology terms or KEGG pathways were found for the down-regulated mRNAs or up-regulated miRNAs.Conclusions: Differentially expressed mRNAs and miRNAs were identified after the administration of DEX in a TBI rat model. The B-cell receptor signaling pathway and the cell cycle pathway might be involved in the neuroprotective effect of DEX against TBI, Lyn and Cdk1 might be hub genes.

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Challenges in the nursing care of intracranial carbapenem-resistant Escherichia coli infection after severe traumatic brain injury: a case report

Cited by 2 publications

References 11 publications

Application of lumbar drainage based on flow control in patients with intracranial infection after craniocerebral surgery

Application of lumbar drainage based on flow control in patients with intracranial infection after craniocerebral surgery

Identification of candidate genes and pathways in dexmedetomidine-induced neuroprotection in rats using RNA sequencing and bioinformatics analysis

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