Dysregulation of sequential and synchronized
events of skin regeneration
often results in the impairment of chronic wounds. Conventional wound
dressings fail to trigger the normal healing mechanism owing to the
pathophysiological conditions. Tissue engineering approaches that
deal with the fabrication of dressings using various biomaterials,
growth factors, and stem cells have shown accelerated healing outcomes.
However, most of these technologies are associated with difficulties
in scalability and cost-effectiveness of the products. In this review,
we survey the latest developments in wound healing strategies that
have recently emerged through the multidisciplinary approaches of
bioengineering, nanotechnology, 3D bioprinting, and similar cutting-edge
technologies to overcome the limitations of conventional therapies.
We also focus on the potential of wearable technology that supports
complete monitoring of the changes occurring in the wound microenvironment.
In addition, we review the role of advanced devices that can precisely
enable the delivery of nanotherapeutics, oligonucleotides, and external
stimuli in a controlled manner. These technological advancements offer
the opportunity to actively influence the regeneration process to
benefit the treatment regime further. Finally, the clinical relevance,
trajectory, and prospects of this field have been discussed in brief
that highlights their potential in providing a beneficial wound care
solution at an affordable cost.
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