Harnessing Multifaceted Next-Generation Technologies for Improved Skin Wound Healing

Abstract

Dysregulation of sequential and synchronized events of skin regeneration often results in the impairment of chronic wounds. Conventional wound dressings fail to trigger the normal healing mechanism owing to the pathophysiological conditions. Tissue engineering approaches that deal with the fabrication of dressings using various biomaterials, growth factors, and stem cells have shown accelerated healing outcomes. However, most of these technologies are associated with difficulties in scalability and cost-effectiveness of the products. In this review, we survey the latest developments in wound healing strategies that have recently emerged through the multidisciplinary approaches of bioengineering, nanotechnology, 3D bioprinting, and similar cutting-edge technologies to overcome the limitations of conventional therapies. We also focus on the potential of wearable technology that supports complete monitoring of the changes occurring in the wound microenvironment. In addition, we review the role of advanced devices that can precisely enable the delivery of nanotherapeutics, oligonucleotides, and external stimuli in a controlled manner. These technological advancements offer the opportunity to actively influence the regeneration process to benefit the treatment regime further. Finally, the clinical relevance, trajectory, and prospects of this field have been discussed in brief that highlights their potential in providing a beneficial wound care solution at an affordable cost.

Healing Wounds Efficiently with Biomimetic Soft Matter: Injectable Self-Healing Neutral Glycol Chitosan/Dibenzaldehyde-Terminated Poly(ethylene glycol) Hydrogel with Inherent Antibacterial Properties

“…The antimicrobial property is one important characteristic of hydrogels intended for wound-healing applications. These hydrogels are capable of reducing the risk of bacterial infection on-site during their application and use, which could consequently impede the regeneration of the skin E.…”

“…These hydrogels are capable of reducing the risk of bacterial infection on-site during their application and use, which could consequently impede the regeneration of the skin. 6 E. coli, P. aeruginosa, and S. aureus are among the most common pathogens that colonize wounds. 44 Pathogen infection leads to dysregulation of the sequential and synchronized events of the wound-healing process.…”

“…Recent developments in biomaterial research have seen prominent interest in the development of new generation matrices (i.e., wound dressing or skin graft) that provide an appropriate mechanical or biochemical environment to aid in the healing process. , Biopolymeric hydrogels are considered excellent candidates for this intention owing to their extracellular matrix (ECM)-mimicking tunable properties such as the water-retention capacity of ten-to-thousand-folds of their equivalent weight, biocompatibility and biodegradability, and support for cells during tissue regeneration . To this end, hydrogels are undoubtedly on the leading edge in the development and advancement of biomimetic soft matter as tissue scaffolds.…”

Internal Wireless Electrical Stimulation from Piezoelectric Barium Titanate Nanoparticles as a New Strategy for the Treatment of Triple-Negative Breast Cancer

“…Physiological electric fields are important factors in the control and regulation of tissue homeostasis, and the use of external ES to regulate cell migration and enhance regeneration of tissues and healing of wounds has become a common practice. , However, the effect of internal wireless ES based on piezoelectric nanomaterials on the migration of carcinoma cells is unclear. To prove the role of ES treatment during metastasis, we designed a wound healing assay.…”

“…Notably, our results demonstrated that internal ES generated by USdriven BTNPs could activate the cell cycle-apoptosis pathway similar to that of TTF, in which BTNPs were involved in regulation as direct effector elements rather than TTF-auxiliary sensitizers. 17 40,41 However, the effect of internal wireless ES based on piezoelectric nanomaterials on the migration of carcinoma cells is unclear. To prove the role of ES treatment during metastasis, we designed a wound healing assay.…”