The aetiological agents of onychomycosis that we found differ from those found in other countries, suggesting that the heat and humidity of the Colombian climate could favour yeast nail infections. The lowest MICs for Candida species (obtained with voriconazole, followed by itraconazole) may be explained by emerging resistant strains. Against dermatophytes, the lowest MICs were obtained with terbinafine, followed by voriconazole. MIC values for the evaluated agents were higher for non-dermatophyte filamentous fungi than for other fungi. As MIC breakpoints have not yet been established for onychomycosis therapies, it remains unclear if in vitro activities of antifungal drugs are predictive of clinical outcome. Well-designed clinical studies are necessary to assist clinicians in choosing the best antifungal agents.

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Two essential oils of Lippia alba (Mill.) N.E. Brown (Verbenacea)

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The first synthesis of lissoclimide-type alkaloids is described. Starting from commercial (+)-sclareolide, the aldehyde-bicyclohomofarnesal is synthesized and coupled, through an aldol reaction, with succinimide. The antitumor activity of several lissoclimide analogues is also reported.