Premenstrual syndrome (PMS) is defined as the recurrence of psychological and physical symptoms in the luteal phase, which remit in the follicular phase of the menstrual cycle. Symptoms of which fall in three domains: emotional, physical and behavioural e.g. irritability, anger, headache, fatigue, food cravings etc. The survey study of was conducted among 50 young & 50 middle aged women of S.B.K.S Medical Institute and Research Centre to find the prevalence of premenstrual syndrome with an emphasis on its management. Responses to a feedback questionnaire covering various aspects related PMS were obtained from 50 participants belonging to each group. The participants belonged to different range of literacy. It was found that 42% faced PMS regularly, while 58% occasionally. Of the 100 participants 68% suffered with backache, 64% leg cramps, 62% fatigue, breast tenderness and anger whereas 58% suffered with anxiety and generalized body ache. Of all the sufferers only 34% had received the treatment for PMS. Irrespective of the age PMS is common problem faced by women. With our study we observed that literacy has not mattered in the management of this health problem. Since there are reports stating that the severity of PMS can hamper the daily routine and even lead to suicidal tendency, it is essential that awareness programs need to be conducted to address the importance of managing the issue by pharmacological and non-pharmacological methods. [Int J Res Med Sci 2013; 1(2.000): 69-72
Background: Liver is the main detoxifying organ, which is affected by most of the drugs and xenobiotic agents that could result in liver damage. The present study was designed to evaluate the hepatoprotective effect of DL-Methionine against experimentally induced liver injury in albino rats.Methods: Hepatotoxicity was induced by administering high doses of positive control drug Diclofenac sodium in albino rats, which was confirmed by estimating Liver Function Tests. Hepatoprotective effect was determined by administering DL- Methionine concomitantly with positive control drug. Albino rats were administered with DL-Methionine (700 mg/kg and 1400 mg/kg) respectively as a single oral dose, concomitantly with positive control drug Diclofenac sodium (96 mg/kg and 240 mg/kg) respectively. After 24-hours of post-treatment, serum levels of the liver enzymes were evaluated to demonstrate the hepatoprotective effect of DL-Methionine on drug-induced hepatotoxicity, and all the liver samples were examined for the histopathological study.Results: Significant increase in serum transaminase enzymes were observed by the positive control drug Diclofenac sodium. There was significant reduction in the serum transaminases on concomitant administration of DL-Methionine with Diclofenac sodium. Liver injury induced by positive control drug; and its protection with DL-Methionine was revealed by histopathological study. The combination of Diclofenac sodium and DL-Methionine showed no significant histopathological difference when compared to the normal liver section.Conclusions: The results reveal that, DL-Methionine significantly prevented the rise in transaminases levels produced by hepatotoxic doses of the positive control drug.
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