Background Preeclampsia (PE) is one of the highest-risk pregnancies and a complicated condition that occurs in 2% to 8% of pregnancies and is associated with markers of a systemic inflammatory response (SIR). In this study, we aimed to determine the role of these markers in predicting PE. Methodology A total of 300 women with singleton pregnancies and cephalic presentation were included in the study. Normotensive pregnant women (n = 149) who met this criterion were included as the control group Pregnant women who met the inclusion criteria for a diagnosis of preeclampsia (n = 151) were included in the study group. Results The baseline characteristics of the study groups showed no significant difference. The hypertensive group was hospitalized significantly earlier than the control group (p < 0.001). We found significantly higher systolic and diastolic blood pressure values in the PE group than in the other group (p < 0.001). The mean neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and aspartate aminotransferase-to-platelet ratio index (APRI) values at hospitalization did not differ significantly between groups (p = 0.639, p = 0.709, and p = 0.066, respectively). In the receiver operating characteristic analysis curves compared with the control group and PE, none of the parameters could predict PE. Conclusions We found that NLR, PLR, and APRI have no clinical significance in assessing developmental risk and predicting PE.
ABSTRACT Aim: Twin pregnancies are associated with increased perinatal mortality and morbidity compared with singleton pregnancies. Single intrauterine fetal death (sIUFD) is difficult to treat. This is because the twin who survives after sIUFD is at high risk for mortality, neurological damage, and other complications of preterm birth. Therefore, in this study, we aimed to determine the perinatal consequences for the surviving fetus. We also investigated the association between chorionicity, maternal characteristics, and fetal and maternal concomitant complications in these cases. Methods: We conducted a retrospective case-control observational study that included twin births complicated by sIUFD followed up in the Department of Perinatology. Data, including demographic characteristics and prenatal invasive procedures, weeks of sIUFD, delivery time, fetal sex, interval between delivery and fetal loss, fetal distress, mode of delivery, birth weight, presence of placental pathology or umbilical cord abnormalities, neonatal Apgar scores in the first and fifth minutes, and need for neonatal intensive care unit (NICU), were obtained from obstetric records and hospital database. Results: Fifty-three twin pregnancies with a single fetal death were included in the study. The mean age of the pregnants participating in the study was 30 (± 6) years. The mean body mass index (BMI) of the mother was 28.8 (22-43). Twenty-four (45.3%) cases were dichorionic (DC) diamniotic, 20 (37.7%) were monochorionic (MC) diamniotic, and 9 (17%) were monochorionic monoamniotic. The time between IUFD and birth of the live twin was 75 days in MCs and 105 days in DCs (p=0.150). The mean gestational age at birth of the surviving twin was 30 weeks’ gestation in MCs and 34 weeks’ gestation in DCs (p=0.030). In 23 (79.3%) MC pregnancies and 15 (62.5%) DC pregnancies, delivery occurred before 37 weeks (p=0.176). In addition, deliveries before 34 weeks occurred more frequently in 19 (65.5%) of MC pregnancies than in 8 (33.3%) of DC pregnancies (p=0.020). Conclusion: We have shown that the birth of the live fetus in the MC group occurred at a significantly earlier time, and mortality and morbidity were observed more frequently in this fetus. However, this research explaining the etiology of sIUFD is insufficient.
AMAÇ: Epitelyal over kanseri kadın kanserleri arasında en mortal olan olup çoğunlukla ileri evrede tanı almaktadır. Evre I high-grade seröz over kanseri tanısı alan ve cerrahi sonrasında adjuvant kemoterapi alan hastaların klinikopatolojik özellikleri ve nüks paternlerinin araştırılması amaçlanmıştır.GEREÇ VE YÖNTEM: Kliniğimizde tedavi görmüş olan 38 high-grade seröz over kanseri nedeniyle total abdominal histerektomi+bilateral salfingooferektomi+pelvik-paraaortik lenf nodu diseksiyon +/- omentektomi yapılan evre I hasta çalışmaya dahil edilmiştir.BULGULAR: Hastaların evre dağılımına bakıldığında Evre IA 10 hasta (%26,3), IB 7 hasta (18,4), IC1 5 hasta (%13,2), IC2 11 hasta (%28,9), IC3 5 hasta (% 13,2) idi. 38 hastanın 11’inde (%28,9) rekürrens gelişti. Rekürrens gelişen hastaların nüks gelişen bölgelere bakıldığında sadece pelvik 1 (%2,6), sadece abdomen 8 (%21,1) iken abdominal + pelvik nüks 1 (2,6) hastada gelişti.SONUÇ: Epitelyal over kanserleri arasında en sık görülen alt grup seröz histolojidir ve genelde ileri evrede tanı alırlar. Erken evrede tanı alan alan hastalarda da nüks oranı yüksektir.
AIM: We investigated whether measurement of triglyceride/glucose index (TyG) and triglyceride/HDL-cholesterol ratio (TG /HDL-c) in the first trimester can predict gestational diabetes mellitus (GDM). MATERIAL AND METHOD: Twenty-five patients with GDM and 52 women without GDM with normal glycemic control during pregnancy were included in the study as a control group. Both insulin-controlled diabetes and diet-controlled diabetes were included in the diagnosis of GDM. Fasting glucose and plasma lipid profiles including TG, HDL-c, TyG index, and TG /HDL-c measured in the first trimester were analyzed. RESULTS: Triglyceride values (mean 133±40 mg/dL in the gestational diabetes group, 100±54 mg/dL in the control group), TyG index (15.0±8.9 in the mean gestational diabetes group, 8.8±5.0 in the control group), and TG/HDL-C ratio (mean 3.3±2.6 in the gestational diabetes group and 1.9±2.6 in the control group) was found to be significantly higher in the GDM group (p=0.01, p=0.01, p=0.01, respectively). The optimal cutoff value for TyG index was 10.4, sensitivity was 76%, specificity was 77%, and area under the receiver characteristic curve (AUC) was 0.765 to predict GDM (p < 0.001). The optimal cutoff value for the TG /HDL-C ratio was 2.3, sensitivity was 76%, specificity was 69, AUC 0.697 to predict GDM (p=0.005). CONCLUSION: TyG and TG/HDL-C ratio measured in the first trimester are thought to predict GDM better than fasting plasma glucose.
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