Inflammatory pseudotumour (IPT) of the spleen is a very rare benign entity that can clinically and radiologically be misconstrued as malignant. We describe a case in a 62-year-old woman who was incidentally found to have a 5.3 cm mass on abdominal ultrasound. On MRI, the mass had irregular margins and internal necrosis, raising suspicion for a malignancy. The woman then underwent a splenectomy. Histology showed a well circumscribed lesion characterised by a proliferation of bland uniform spindle cells in a background dense mixed inflammatory infiltrate consisting of lymphocytes, plasma cells and eosinophils. Immunohistochemistry showed positivity of the spindle cells for SMA and focally for CD68. There was a background predominant CD3 positive T lymphocyte population. An extensive follicular dendritic cell network was not identified on CD21. EBER in situ hybridisation was positive. The findings were consistent with an inflammatory pseudotumour of the spleen.
clinical management decision-making to include wide local reexcision, sentinel node biopsy and long term follow-up. References 1.Sekoranja D, Pi zem J, Luzar B. An update on molecular genetic aberrations in Spitz melanocytic proliferations: correlation with morphological features and biological behavior.
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