Prevalence of genetic mutations in lung adenocarcinoma: A study from St George hospital

Abstract

Inflammatory pseudotumour (IPT) of the spleen is a very rare benign entity that can clinically and radiologically be misconstrued as malignant. We describe a case in a 62-year-old woman who was incidentally found to have a 5.3 cm mass on abdominal ultrasound. On MRI, the mass had irregular margins and internal necrosis, raising suspicion for a malignancy. The woman then underwent a splenectomy. Histology showed a well circumscribed lesion characterised by a proliferation of bland uniform spindle cells in a background dense mixed inflammatory infiltrate consisting of lymphocytes, plasma cells and eosinophils. Immunohistochemistry showed positivity of the spindle cells for SMA and focally for CD68. There was a background predominant CD3 positive T lymphocyte population. An extensive follicular dendritic cell network was not identified on CD21. EBER in situ hybridisation was positive. The findings were consistent with an inflammatory pseudotumour of the spleen.