Hematologic studies, including bone marrow examinations, have been done on a series of rats which were on a magnesium-deficient diet, with or without 2-AAF supplementation. Leukocytosis and granulocytosis could be maintained in these deficient rats by decreasing their intake of magnesium and could be reversed by the addition of magnesium. The bone marrows of the magnesium-deficient group showed granulocytic hyperplasia; the bone marrows of the deficient 2-AAF supplemented rats showed erythrocytic hyperplasia, as well as granulocytic hyperplasia. Chronic granulocytic leukemia developed in two magnesium deficient rats and persisted after magnesium supplements were given. This leukemia has been successfully transplanted into newborn rats.
An automated tape-recording unit for use in screening large populations of school children for heart disease has been developed and field tested. A technician can produce good quality apex and base heart sound recordings from 250 children during an average school day. The physician can listen to these recordings at a rate of 140 children per hour, recalling for examination each child considered to have an abnormal recording. Since almost all heart disease in children has some acoustic manifestation, a screening technic based on the heart sounds seems to be a logical one. The studies done with this unit have demonstrated its ability to select children with heart disease from a large number of normal children. Agreement between readers is satisfactory, and the number of "false positives" is considered reasonable.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.