Adipose tissue is a major store of energy for the human body. Polycystic ovary syndrome (PCOS) patients are more prone to abnormal production of some regulatory proteins secreted from the adipose tissue. This study aims to investigate serum levels of adiponectin and their correlation with metabolic and endocrine indices in PCOS. Patients and methods. This study was conducted on 61 women with PCOS and 17 healthy women whose age and body mass index (BMI) were matched. Adiponectin serum levels were assessed and correlated with parameters of metabolic and hormonal disturbances. Results. In PCOS women, serum levels of insulin, HOMA-IR, testosterone, LH, and LH/FSH were significantly higher, while SHBG was lower than in healthy women. Lower adiponectin was observed in both PCOS groups compared to the control group. Serum levels of adiponectin correlated inversely with BMI (r=-0.56; p<0.001),WC(r =-0.452;p<0.001), insulin levels (r=-0.409; p<0.001), HOMA-IR (r=-0.368; p<0.001), and free androgen index (FAI) (r=-0.53; p<0.001). A positive correlation was found between adiponectin and LH (r= 0.35; p<0.001), LH/FSH ratio (r= 0.33; p<0.001) and SHGB (r= 0.51; p<0.001). Serum adiponectin levels are decreased in women with PCOS compared to the control group. The decrease in adiponectin concentration indicates its potential role in metabolic disorders in the pathogenesis of PCOS, as well as in the development and progression of insulin resistance in PCOS patients.

No abstract

No abstract

Background. The amplification and the overexpression of the

A large number of hospitalized COVID-19 survivors show that persistent symptoms, radiographic abnormalities and physiological impairments exist months after the initial illness. Persistent chest imaging abnormalities and histopathological findings of lung fibrosis were also found in a majority of survivors of the SARS-CoV-1 suggesting that the SARS viruses may lead to a worse fibroproliferative response than other pneumonias.Our patient had a severe COVID-19 pneumonia, followed by massive infiltrative changes in both lungs in addition to massive pulmonary fibrosis. After the initial treatment in one of the COVID-19 centers in the Clinical Center in Skopje, the patient with post-COVID-19 (more precisely pulmonary fibrous changes of the lungs) was referred for further treatment to the University Clinic for Pulmonology in a severe clinical condition, where he was treated at an outpatient basis in the period of several months. During that time the condition improved, with a significant withdrawal of the X-ray finding of the lungs, which was registered on CT from 5.5.2021. He is still under observation.The robust responses of corticosteroid therapy in our case presenting a radiological pattern of organizing pneumonia allowed the patient to return to his baseline clinical condition. But due to the persistence of X-ray residual changes he is under our regular observation.