Hormonal and adiposity state of women with polycystic ovary syndrome: Implication of adipocytokines

Boshku, Aleksandra Atanasova; Ivanovska, Beti Zafirova; Mishevsk, Sasha Jovanovska

doi:10.1016/j.atherosclerosis.2017.06.813

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“…The correlation trends between the androgen and endocrine indices in the present study is supported by previously published studies that have shown that the androgen receptor might have an effect on apoptosis of ovarian granulosa cells apoptosis, granulosa cell death, reducing antral follicles, led to ineffective effects on the ovary by pituitary gonadotropin secretion, and leading to premature ovarian senility [ 23 , 24 ]. This study also showed that there was a correlation between androgen levels, the FAI, androstenedione, luteinizing hormone (LH), estradiol (E2), and follicle-stimulating hormone (FSH) in two study groups, indicating that androgens can affect follicular development.…”

Section: Discussionsupporting

confidence: 88%

Comparison of Androgen Levels, Endocrine and Metabolic Indices, and Clinical Findings in Women with Polycystic Ovary Syndrome in Uygur and Han Ethnic Groups from Xinjiang Province in China

et al. 2018

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BackgroundThe aim of this study was to compare androgen levels, endocrine and metabolic indices, and clinical findings in women with polycystic ovary syndrome (PCOS) in Uygur and Han ethnic groups from Xinjiang Province, China.Material/MethodsBetween January 2016 to May 2017 clinical data were collected from Uygur (N=82) and Han (N=100) women diagnosed with PCOS, including age, body mass index (BMI), the Ferriman-Gallwey (mFG) hirsutism score, and waist-to-hip ratio (WHR). Blood samples obtained from all study participants were used to measure androgenic steroid levels, including androgen, androstenedione, dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT), and the free androgen index (FAI). Endocrine indices measured included sex-hormone binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), and prolactin (PL). Metabolic indices measured included insulin, glucose, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), triglyceride (TG), and low-density lipoprotein (LDL).ResultsThe FAI in Uygur women with PCOS (4.89) was significantly increased compared with Han women with PCOS (2.78) (p<0.05); androgen levels were significantly correlated with the FAI, glucose, insulin, TC, HDL, and LDL (p<0.05); androstenedione levels were positively correlated with glucose and insulin levels (p<0.05). In Han women with PCOS, androgen levels were negatively correlated with TG levels and positively correlated with TC levels (p<0.05); the FAI was positively correlated with glucose and insulin levels (p<0.05).ConclusionsThere were significant differences in androgen levels, endocrine, and metabolic indices in women with PCOS between the Uygur and Han ethnic groups from Xinjiang Province in China.

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Section: Discussionsupporting

confidence: 88%