Bertrand Poirier scite author profile

The effect of pepsin treatment at pH 4 on the infectivity of several enveloped viruses was assessed under the conditions used during the production of intravenous immunoglobulins. It was shown that the prototypes of four virus families--human immunodeficiency virus (Lentivirinae), herpes simplex virus type 1 and human cytomegalovirus (Herpesviridae), Semliki Forest virus (Togaviridae), and vesicular stomatitis virus (Rhabdoviridae)--were inactivated by this procedure. With vesicular stomatitis virus as a model, the contributions of both low pH and pepsin were demonstrated, and pepsin had a synergistic or additive action.

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Replacement of in vivo human rabies vaccine potency testing by in vitro glycoprotein quantification using ELISA – Results of an international collaborative study

Morgeaux

Poirier²,

Ragan³

et al. 2017

Vaccine

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Inactivated rabies vaccine control and release:use of an ELISA method

et al. 2003

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A relevant in vitro ELISA test in alternative to the in vivo NIH test for human rabies vaccine batch release

Gibert¹,

Alberti²,

Poirier³

et al. 2013

Vaccine

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Key Points for the Development of Mouse Immunogenicity Test as Potency Assay for Acellular Pertussis Vaccines

et al. 2000

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Establishment of a national network of validated and qualified laboratories for neutralizing anti-vaccinia antibodies titration

et al. 2005

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Would an in vitro ELISA test be a suitable alternative potency method to the in vivo immunogenicity assay commonly used in the context of international Hepatitis A vaccines batch release?

Poirier¹,

Variot²,

Delourme³

et al. 2010

Vaccine

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