Plasmodium falciparum, the agent of malignant malaria, is one of mankind's most severe scourges, mainly in the tropic world. Efforts to develop preventive vaccines or remedial drugs are handicapped by the parasite's rapid evolution of drug resistance. Here, we presented an advance work on examination of antimalarial component from marine life of Xestospongia sp., the study is based on hexane extraction method. The premier result, we obtained five fractions. Among these five fractions, the fourth has the most potent inhibitory against the growth of P. falciparum 3D7 with an IC50: 7.13 µg/mL. A compiled spectrum analysis, FTIR, 1H-NMR and GC-MS, revealed that the fourth fraction consisted abundantly of two secondary metabolites such as flavonoids and triterpenoids. Finally, our results suggest a plausible structure rooted to the base of ibuprofen.

86 Studi adsorpsi limbah organik industri tahu tempe dengan karbon aktif kayu merbau [Intsia bijuga (Colebr) O. Kuntze] Study of adsorption of organic waste from tofu and tempe with activated carbon of merbau wood [Intsia bijuga (Colebr) O. Kuntze] ABSTRACT: Study on adsorption of tofu and tempe industrial organic waste with timber wood [Intsia bijuga (Colebr) O. Kuntze] as the active carbon has been executed. The objective the research is to determine the optimum required consentration of HCl to active the coal of timber wood, discover optimum adsorption capacity of timber charcoal to reduce the level of BOD5 dan COD in fluids waste of tofu and tempe industry. Research method of activating timber wood charcoal is physically by heating 700 o C of temperature and chemically by submersion in HCl 1M, 2M and 3M. First, variation is made of contact duration of timber wood active carbon and fluid waste for 30, 60, 90 and 120 minutes. Then, volume of fluid waste is also differed by 100, 150, 200, 250 and 300 ml per 0.5 gram of active carbon. Result of the research shows that optimum condition for adsorption of tofu and tempe industrial fluid waste are as follow : at consentrate of HCl 3M, contact duration 30 minutes, fluid waste volume 250 ml per 0.5 gram of active carbon, optimum adsorption capacity of timber wood active carbon is achieved which lowering the level of BOD5 and COD of Rizky tofu and tempe industrial fluid waste; each by 60,600 mg/g and 12,500 mg/g. On the state where volume of the waste is 100 ml per 0.5 gram, optimum adsorption capacity of the timber wood active carbon in reducing the BOD5 and COD level of Sukamaju tofu and tempe industrial fluid waste is 82,400 mg/g and 164,200 mg/g each. Keyword : Adsorption, BOD5, COD, tofu and tempe industrial fluid waste, active carbon, wood. ABSTRAK: Studi tentang adsorpsi limbah organik industri tahu dan tempe dengan kayu kayu [Intsia bijuga (Colebr) O. Kuntze] ketika karbon aktif telah dieksekusi. Tujuan dari penelitian ini adalah untuk menentukan konsentrasi HCl yang diperlukan untuk mengaktifkan batubara kayu kayu, menemukan kapasitas adsorpsi arang kayu yang optimal untuk mengurangi tingkat BOD5 dan COD dalam limbah cair industri tahu dan tempe. Metode penelitian untuk mengaktifkan arang kayu kayu secara fisik dengan memanaskan suhu 700oC dan secara kimiawi dengan perendaman dalam HCl 1M, 2M dan 3M. Pertama, variasi dibuat dari durasi kontak karbon aktif kayu dan limbah cair selama 30, 60, 90 dan 120 menit. Kemudian, volume limbah cair juga berbeda dengan 100, 150, 200, 250 dan 300 ml per 0,5 gram karbon aktif. Hasil

The purpose of this research is  to study the potency of chitosan synthesis of shrimp shells from Bintuni as a biosorbent of organic compound and heavy metal compound. The main procedure of chitosan synthesis is completed by insulating chitin from shrimp shells and then chitin is deacetilated to transform chitin to be chitosan. The wastewater were characterized to know the concentration of Total Organic Carbon (TOC), fat oil, and Zinc metal and studied the adsorption of each compound at 0,1; 0,5; 1; 2g  dosage chitosan.  Adsorption study result showed that chitosan can adsorb the fuel oil and Zinc metal which contained in wastewater. However, it was not adsorb the TOC compound. The yield of chitosan is 46,88%. Increasing the chitosan by up to 2 g resulted  in the creasing of the adsorption effectiveness up to 99,09% for the fuel oil and 69,28%  for Zinc. The maximum chitosan adsorption capacity accomplished at 0,1gram  chitosan in 100 mL wastewater.

Freundlich and Langmuir Isotherms Model by Active Chorcoal Adsorbent Bamboo Andong  (G. verticillata (Wild) Munro) and Bamboo Ater (G. atter (Hassk) Kurz ex Munro)          Diazinon insecticide adsorption by two types of adsorbent, namely activated charcoal bamboo andong (G. verticillata (Wild) Munro) and bamboo ater (G. atter (Hassk) Kurzex Munro) at optimum conditions determined the maximum adsorption capacity of both types of adsorbent. Data analysison the effect of concentration on the adsorption capacity was used Langmuir and Freundlich isotherms equation. It was obtained. That  the curve of adsorption isotherms of the Langmuir isotherm better modeled with linear regression coefficients were relatively more approach 1 is R2 = 0,996 for both types of adsorbents. Langmuir isotherm equation obtained from adsorpsi maximum capacity of activated charcoal bamboo andong (G. verticillata (Wild) Munro) of  4.630 mg/g (1,433.10-5 mol/g) with K = 0,332 (Kmol/L)-1 and Eads at -2,750 kJ/mol, while the activated charcoal bamboo ater (G. atter (Hassk) Kurzex Munro) produce the maximum adsorption capacity of 1,786 mg/g (5,868.10-6 mol/g) with K = 0,202 (Kmol/L)-1 and Eads = -3,898 kJ/mol, so the adsorption of both types of adsorbents indicated experiencing a physical adsorption (physisorption / fisisorpsi).Keyword: G. verticillata (Wild) Munro, G. atter (Hassk) Kurz ex Munro, Adsorption, Diazinon,  actived charcoal  ABSTRAK          Adsorpsi insektisida diazinon oleh dua jenis adsorben, yaitu arang aktif bambu andong (G. verticillata (Wild) Munro) dan bambu ater (G. atter (Hassk) Kurz ex Munro) pada kondisi optimum bertujuan untuk menentukan kapasitas adsorpsi maksimum dari kedua jenis adsorben. Analisis data pengaruh konsentrasi terhadap kapasitas adsorpsi digunakan persamaan isoterm Langmuir dan Freundlich. Berdasarkan data yang diperoleh, kurva isoterm adsorpsi lebih mengikuti model isoterm Langmuir dengan koefisien regresi linier yang relatif lebih mendekati 1 yaitu R2 = 0,996 untuk kedua jenis adsorben. Dari persamaan isoterm Langmuir diperoleh kapasitas adsorpsi maksimum arang aktif bambu andong (G. verticillata (Wild) Munro) sebesar 4,630 mg/g (1,433.10-5 mol/g) dengan K = 0,332 (Kmol/L)-1 dan Eads sebesar -2,750 kJ/mol, sedangkan arang aktif bambu ater (G. atter (Hassk) Kurz ex Munro) menghasilkan kapasitas adsorpsi maksimum sebesar 1,786 mg/g (5,868.10-6 mol/g) dengan K = 0,202 (Kmol/L)-1 dan Eads = -3,898 kJ/mol, sehingga adsorpsi kedua jenis adsorben diindikasikan mengalami adsorpsi secara fisik (physisorption/ fisisorpsi).Kata kunci : G. verticillata (Wild) Munro, G. atter (Hassk) Kurz ex Munro Adsorpsi, Diazinon, Arang aktif