Visual stimulation by repetitive flashes of light can lead to an entrainment of the alpha rhythm in electroencephalogram recordings (also called photic driving). We report a comparison of simultaneously recorded electric and magnetic data in a photic driving experiment, adapted to the individual alpha rhythm of 10 healthy volunteers. We show that there is a stronger frequency entrainment in magnetoencephalogram than in electroencephalogram recordings in all volunteers, which indicates a possible tangential brain activity underlying the dominant entrainment effect. The entrainment in the magnetoencephalogram lasts over significantly more frequencies and is most effective in the region around the individual alpha and a half alpha. For different channels, we found different degrees of entrainment showing topological and time-varying properties.

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Biomagnetic measurement performed outside a magnetically shielded room is subject to distortion by strong magnetic fields. Reducing such disturbances can enhance and stabilize biomagnetic measurement conditions in the absence of passive shielding. We have developed an active magnetic shielding system that produces both homogeneous and spatial gradient magnetic fields. The system is composed of anisotropic magnetoresistive sensors, a digital signal processor controller and two different coil systems. In order to improve the measurement environment for a first-order gradient coil SQUID system, the disturbing vertical magnetic fields and vertical field gradients are reduced, thus achieving a shielding factor of approximately 6 at 100 Hz. Our system provides a more flexible and less costly alternative to magnetically shielded rooms.

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BackgroundMagnetically marked capsules serve for the analysis of peristalsis and throughput times within the intestinal tract. Moreover, they can be used for the targeted disposal of drugs. The capsules get localized in time by field measurements with a superconducting quantum interference device (SQUID) magnetometer array. Here it is important to ensure an online localization with high speed and high suppression of disturbing fields. In this article we use multipole expansions for the simultaneous localization and suppression of disturbing fields.MethodsWe expand the measurement data in terms of inner and outer multipoles. Thereby we obtain directly a separation of marker field and outer disturbing fields. From the inner dipoles and quadrupoles we compute the magnetization and position of the capsule. The outer multipoles get eliminated.ResultsThe localization goodness has been analyzed depending on the order of the multipoles used and depending on the systems noise level. We found upper limits of the noise level for the usage of certain multipole moments. Given a signal to noise ratio of 40 and utilizing inner dipoles and quadrupoles and outer dipoles, the method enables an accuracy of 5 mm with a speed of 10 localizations per second.ConclusionThe multipole localization is an effective method and is capable of online-tracking magnetic markers.