Background: Telemedicine is seen as a savior during the COVID-19 pandemic. Materials & methods: This study is a descriptive cross-sectional study conducted with cancer patients who were interviewed via telemedicine from a tertiary care comprehensive oncology center. Results: A total of 421 patients were included in the study and 118 of them (28.0%) were >65 years old. Communication was provided most frequently by voice call (n = 213; 50.5%). The majority of the patients contacted by telemedicine had breast cancer (n = 270; 64.1%). For 135 patients (32.1%) no further examination or intervention was required and the previously planned follow-up visit was postponed by the clinician. Conclusion: This study showed that telemedicine could open a new era for medical oncology specialists.
Background: Previous studies have observed an association between ABO blood group and risk for certain gastrointestinal malignancies, including pancreatic and gastric cancer. However, it is unclear whether there is such an association with colorectal cancer (CRC). In this study, possible relationships between ABO blood groups and Rh factor and KRAS status in patients with CRC were investigated. Materials and Methods: In 1,620 patients with CRC, blood group and Rh factor were examined and compared with the control group of 3,022,883 healthy volunteer blood donors of the Turkish Red Crescent between 2004 and 2011. The relationship of blood groups with wild type K-ras status was also evaluated. Results: Overall distributions of ABO blood groups as well as Rh factor were comparable between patients (45% A, 7.2% AB, 16.4% B, 31.4% O, and 87.2% Rh+) and controls (42.2% A, 7.6% AB, 16.3% B, 33.9% O, and 87.7% Rh+) (p=0.099). However, there were statistically significant difference between patients and controls with respect to O vs. non O blood group (p=0.033) and marginally significant difference for A vs. non-A blood group (p=0.052). Among patients, the median age was 62 (range 17-97), 58.1% were male. There were no statistically significant differences respect to sex and K-ras status. Conclusion: In present study, the ABO/Rh blood groups were statistically significantly associated with the risk of CRC. There were no relationship between K-ras status and ABO blood group and Rh factor. However further studies with larger numbers of patients are needed to establish the role of blood groups and to define the mechanisms by which ABO blood type affect CRC.
Background:CSE1L (chromosome segregation 1-like) is the human homologue to the yeast gene CSE1, and is related to invasion and metastasis in cancer progression. The aim of this study was to investigate the potential role of CSE1L expression in distant metastasis of breast cancer. Patients and Methods: A total of 71 breast cancer patients were included in this study. Clinical characteristics and CSE1L status were evaluated. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded archival breast tumor tissue. The results of CSE1L staining were analyzed according to the percentage of immunoreactive cells. Results: 34 patients had distant metastasis and 37 did not. The mean age of the patients was 50.5 ± 12.1 years. Age, tumor size, and hormone receptor status were similar in patients with distant metastasis and in those without. A statistically significant relationship was found between nuclear CSE1L expression and distant metastasis of breast cancer. Lymph node metastasis and nuclear grade were other factors affecting distant metastasis. Conclusion: There is a relationship between nuclear CSE1L overexpression and distant metastasis in breast cancer. CSE1L status may therefore become a valuable prognostic tool in the future.
Most of the acute pancreatitis cases are due to cholelithiasis and alcohol intake. Two percent of the cases are related to medications. Drugs including ACE (angiotensin-converting enzyme) inhibitors and thiazide diuretics may cause acute pancreatitis. Patients with biliary system disorders using certain drugs may develop acute pancreatitis and this may be confusing when considering the aetiology. We report a patient without any known risk factor who developed acute pancreatitis shortly after the intake of lisinopril and hydrochlorothiazide. Common bile duct stone and biliary sludge were diagnosed after physical and radiological evaluation.
ÖZET(times new roman, 10 punkto, Ortalı,kalın, çizgiden bir boşlukla ayrılarak) GİRİŞ ve AMAÇ: COVID-19 krizi sürecinde kanserli hastalarının bakımı ile ilgili önemli sorunlar bulunmaktadır. Bu hasta grubunun hem kanser tedavilerinin gecikmesi ile karşılaşılabilecek önemli mortalite riski hem de kemoterapi, radyoterapi, immünoterapi gibi antikanser tedavilerine bağlı gelişebilecek immünsüpresif durumları nedeniyle olası SARS-Cov-2 enfeksiyonu sırasında kötü prognoz ve mortalite riski bulunmaktadır. Bu nedenle pandemi dönemlerinde kanser hastalarının tedavilerinin devam etmesi ve enfeksiyon riskinin en aza indirilmesi için önemli tedbirler alınması gerekmektedir. Biz de tüm bu sorunlara cevap bulmak amacıyla hastanemiz acil servis, pandemi polikliniği, medikal onkoloji polikliniklerine COVID-19 bulguları ile başvurmuş solid malignite tanılı hastalarımızı retrospektif olarak taramayı amaçladık YÖNTEM ve GEREÇLER: 11 Mart 2020 -11 Mayıs 2020 tarihleri arasında Ankara Dr. A. Yurtaslan Onkoloji Eğitim ve Araştırma Hastanesi medikal onkoloji polikliniği, acil servis ve pandemi polikliniğine COVID-19 hastalığı semptom ve/veya bulguları ile başvuran ve daha önce solid organ malignitesi tanısı olan, tıbbı onkoloji kliniğimizde takipli 76 hasta retrospektif olarak incelendi. BULGULAR: Başvuruda en sık görülen semptomlar;kuru öksürük (33, %43.4), ateş (23, % 30.3), yorgunluk (23, %30.3) ve dispne (23, %30.3) idi. Otuz dokuz vakaya (%51.3) COVID-19 rRT-PCR testi yapıldı.Dört hastanın (%5.2), COVID-19 rRT-PCR testi pozitif sonuçlandı.Bu sayı, aynı dönemde polikliniğimize başvuran yaklaşık altı bin kanser tanılı hastalarımızın % 0.06 'sını oluşturuyordu. rRT-PCR testi pozitif hastalar; evre 2 meme ca, 2. basamak kemoterapi alan mesane ca ve kemonaif evre 4 mide ca olup yoğun bakıma ünitesine yatışları gerekmedi ve iyileşmiş olarak taburcu oldukları öğrenildi TARTIŞMA ve SONUÇ: Bulgularımız, mevcut pandemide kanser hastalarının daha kötü seyrini ve mortalitesini desteklememektedir. Bu durumun hastanemizin, onkoloji ağırlıklı hizmete devam edilmesi nedeniyle nisbeten korunaklı olup aktif covid hastasının takip edilmemesinin yanısıra çalışma sistemimizde yaptığımız önemli değişikliklerden dolayı (triyaj, polikliniklerde yer değişikliği yaparak sosyal mesafe korunması, maske takılması, remisyondaki kontrol hastaları, kemoterapi öncesi semptom sorgulama ve danışma için kullanılan teletıp uygulamaları gibi) kanser hastalarının hastaneye geliş sıklıklarını azaltarak, COVID-19 enfeksiyon riskini azalttığımızı düşünmekteyiz.
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