LCMV evades B cell responses by recruiting inflammatory monocytes to draining lymph nodes. See related Research Articles by Fallet et al. and Moseman et al. and a Focus by Laidlaw et al.

Interferon-driven inflammation in chronic viral infection blocks generation of sustained B cell responses. See related Research Articles by Moseman et al. and Sammicheli et al. and a Focus by Laidlaw et al.

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Highlights d Chronic viral infection elicits potent and sustained germinal center (GC) responses d Chronic infection triggers prolonged plasma cell and memory B cell output from GCs d GC B cells hypermutate efficiently and are potently selected in chronic infection