Behçet’s-like adverse event or inaugural Behçet’s disease after SARS-CoV-2 mRNA-1273 vaccination?

Aseptic Meningitis, Mucocutaneous Lesions and Arthritis after COVID-19 Vaccination in a 15-Year-Old Boy

“…Table 1 displays clinical and biochemical characteristics of our case in comparison with the five previously reported patients with aseptic and pathogen-negative meningitis (Table 1). Saito et al reported a considerable fraction of granular cells in the CSF pleocytosis [6], as also seen in our patient, whereas the remaining patients presented with an almost exclusive mononuclear cell pleocytosis [3][4][5]7]. On the other hand, the patient of Saito et al is the only one who was reported to have a normal CSF protein level [6].…”

“…On the other hand, the patient of Saito et al is the only one who was reported to have a normal CSF protein level [6]. In addition, clinical meningitis symptoms in two patients [3,5] were already present on the first day after vaccine administration, as opposed to a period of at least one week in the other patients [4,6,7]. Of note, the patient reported by Tagini et al did not present clinical signs of meningitis, and CSF analysis was primarily performed due to ophthalmological and cMRI findings suggestive of intracranial hypertension.…”

“…To date, all reported cases of aseptic and pathogen-negative meningitis occurred after immunization with mRNA vaccines [3][4][5][6][7], and all except one [7] after the BNT162b2 vaccine. This may simply reflect the fact that BNT162b2 currently is the most commonly administered COVID-19 vaccine in many regions worldwide.…”

“…Along with an increasing number of individuals being immunized worldwide, descriptions of rare but serious neuroinflammatory conditions such as Guillain-Barré syndrome (GBS) and transverse myelitis observed in close temporal relation with COVID-19 vaccinations led to considerations on specific neurological adverse reactions, although causality is still a matter of debate [1,2]. Recently, a few adult patients with aseptic meningitis possibly triggered by a COVID-19 vaccination have been described [3][4][5][6][7], one of which presented additional mucocutaneous and ocular symptoms leading the authors to consider the differential diagnosis of a first episode of Behçet's disease [7]. Here, we report the first juvenile patient who developed aseptic meningitis with accompanying mucocutaneous lesions and arthritis resembling a Behçet's disease episode in close temporal association with the COVID-19 vaccine BNT162b2 (Comirnaty, Pfizer/BioNTech, New York, NY, USA/Mainz, Germany).…”

Vulvar Aphthous Ulcer and COVID-19 mRNA Vaccination

“…For post CPVOD-10 vaccination vulvar apthous ulcer, it is necessary for further investigation and monitoring of clinical symptom. The genital ulcer might be the first presentation of Behcet's disease and Behcet's disease is a rare problem observed following COVID-19 vaccination [2] . For a possible pathogenesis, COVID-19 vaccination can induce a hyperviscosity problem [3] and hyperviscosity is a rare but possible clinical problem associated with Behcet's disease [4] .…”