The mission of the National Institute on Drug Abuse (NIDA) is to lead the nation in bringing the power of science to bear on drug abuse and addiction. Within NIDA, the Prevention Research Branch (PRB) supports a developmentally grounded program of research on the prevention of initiation of drug use, progression to abuse and dependence, and transmission of drug-related HIV infection. This research involves the use of rigorous scientific methods to test theoretically derived hypotheses to advance our understanding of the science of prevention within diverse populations and settings. Studies that support this purpose include: investigations of cognitive, behavioral, and social processes as they relate to the development of novel prevention approaches; tests of the efficacy and effectiveness of newly developed and/or modified (adapted) prevention programs; studies of services research questions on the processes associated with the selection, adoption, adaptation, implementation, sustainability, and cost-effectiveness of science-based interventions; and the development of methodologies appropriate for studying complex aspects of prevention science. These programs of research are intended to provide pathways toward the discovery of population-level approaches for the prevention of drug abuse and dependence, drug-related problems (such as mental health, interpersonal violence, criminal involvement, and lost productivity), and drug-related diseases and disorders (e.g. HIV/AIDS, hepatitis B, and C, or comorbid drug and psychiatric disorders) across the life course.The services research component of the PRB portfolio has its origins in the 1992 legislation that authorized the creation of NIDA as one of the NIH research institutes. That authorization mandated a budget set aside for the conduct of prevention-and treatment-services research. Initially, the majority of services research focused on treatment. However, the development and testing of efficacious and effective drug abuse interventions using randomized controlled trials led to discussions of how to promote the wide-scale implementation and dissemination of prevention interventions. Early prevention-services research questions addressed the barriers and enhancers to wide-scale dissemination through existing and created service systems. Over time, this portfolio has become both larger and more sophisticated, partly through requests for application (RFA) initiatives to promote an understanding of programmatic-level questions and systems-or implementation-level questions related to moving evidencebased interventions (EBIs) into wide-scale implementation. There also was a growing understanding that for largescale implementation and dissemination to occur, a thorough grasp of what works in specific contexts and locales and the processes that contribute to decision-making, selection, adoption, adaption, implementation, evaluation, financing and sustainability of EBIs was needed. Moreover, partnerships between researchers and community stakeholders/practitioners were seen...