A simple and convenient method for one-pot synthesis of a series of potentially biologically active [1,2,4]triazolo[1,5- a]pyrimidine-6-carboxamide derivatives has been developed in solvent-free conditions using maltose as a commercially available, cheap and eco-friendly catalyst. The salient features of the present protocol are mild reaction conditions, good to excellent yields, high atom economy, benign environmental conditions, easy isolation of products without column chromatography and clean reaction profiles.
Abstract. An eco-friendly and environmentally benign synthesis of 3,4,5-substituted furan-2(5H)-ones employing Iranian seedless barberry, known as Zereshk, (Berberis integerrima "Bidaneh", Berberidaceae) as a biocatalyst, was developed. For the fi rst time, we found that the barberry juice could be effectively used for three-component condensation reaction of aldehydes, amines, and dialkyl acetylenedicarboxylates. The merits of this method include the environmentally friendly reaction conditions, simple operation, broad substrate, satisfying yields, and the generation of less waste rather than the conventional chemical reagents.
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