Extract of Barberry as Entirely Green Catalyst for the Synthesis of Structurally Diverse 3,4,5-Substituted Furan-2(5H)-Ones

Abstract

Abstract. An eco-friendly and environmentally benign synthesis of 3,4,5-substituted furan-2(5H)-ones employing Iranian seedless barberry, known as Zereshk, (Berberis integerrima "Bidaneh", Berberidaceae) as a biocatalyst, was developed. For the fi rst time, we found that the barberry juice could be effectively used for three-component condensation reaction of aldehydes, amines, and dialkyl acetylenedicarboxylates. The merits of this method include the environmentally friendly reaction conditions, simple operation, broad substrate, satisfying yields, and the generation of less waste rather than the conventional chemical reagents.

From traditional to greener alternatives: potential of plant resources as a biotransformation tool in organic synthesis

“…Next, Sahoo and co-workers exploited hydroamination chemistry as a foundation to achieve 53 (Fig. 9); with lemon juice as a catalyst, 91 it required high thermal energy but when Maghsoodlou and fellow workers swapped lemon with barberry juice, 92 the reaction produced 53 (Fig. 9) with more than 90% yield in 3 h at room temperature.…”

Lemon Juice: A Versatile Biocatalyst and Green Solvent in Organic Transformations

“…Further, by employing seedless barberry (Berberis integerrima), Hazeri et al . reported the synthesis of furan‐2(5)‐ones using the same reaction conditions [76] . However, this reaction provided moderate yields compared to lemon juice biocatalyst‐based reactions.…”