A simple and mild protocol for copper catalyzed halogenation of quinoline at C5 and C7 positions was developed, affording the desired remote C-H activation products in moderate to good yields. This reaction proceeds with low-cost sodium halides (NaX, X = Cl, Br, I) and features excellent substrate tolerance. A series of control experiments were carried out to illustrate a single-electron-transfer process which plays a vital role in the halogenation.

A simple low-energy and efficient method is established for the synthesis of C5-selective perfluoroalkylation quinolines in the absence of any transition metal catalysts.

Exploring ap otential catalyst system for catalyst-controlled selectivity in CÀSb ond formation is af ascinating challenge. Herein, we described two novel and highly efficient methods for the selectives ynthesis of C2-and C3-sulfonylindoles showing good biological activities by employing iodide and copper catalysts, respectively.M echanistic studies point to the crucial role of the electronic properties of the sulfonylated intermediates.

Nickel or iron salts catalyzing the selective synthesis of 3,3‐indolyl disulfide (diselenide) and 3,3‐indolyl thioether (selenide) directly from indole through C−H activation are reported. The effect of iodine element was beneficial in the novel metal‐catalyzed circulation system. A wide variety of functional groups could be tolerated under the reaction conditions.