The first example of oxidative C−H fluoroalkoxylation of quinoxalinones with fluoroalkyl alcohols under transition-metal and solvent-free conditions is described. This approach provides the synthesis of fluoroalkoxylated quinoxaline derivatives with good to excellent yields under mild reactions conditions. This method can also be extended to the facile and efficient synthesis of histamine-4 receptor.F luorine-containing molecules have found important applications in drug discovery, agricultural chemicals, and materials science. 1 Fluoroalkoxyl aryl ethers are among those that have received much attention, because of the unique properties such as good electron-withdrawing effect and the significant lipophilicity of the fluoroalkoxyl group (Scheme 1). 2
Mesoporous
silica-supported spinel phase CuCo2O4 mixed-metal
oxide nanoparticles were synthesized as a catalyst
for the selective oxidation of substituted benzyl alcohols to aromatic
aldehydes, in which oxygen gas was used as an oxidant. It possessed
high catalytic activity, achieving nearly 100% conversion in 8 h,
which was much higher than mesoporous silica-supported CuO nanoparticles,
Co3O4 nanoparticles, and their mixtures, demonstrating
the advantage of mixed metal oxide due to its unique electronic states.
The enhanced catalytic activity of CuCo2O4 may
come from the presence of Cu3+ in the octahedral sites
of the spinel phase crystal structure. A self-supported mesoporous
CuCo2O4 replica material with same crystal phase
was also synthesized. However, it was found that the self-supported
replica material gave much lower reactivity in this reaction, which
may be because the surface copper ions were preferentially etched
by NaOH during the template removal process.
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