Purpose: To determine the effect of natural clinoptilolite (CLN) and nano-sized clinoptilolite (NCLN) on lipid profile, food intakes (FI) and weight changes in streptozotocin (STZ) induced diabetic rats.Methods: In this experimental study, 36 rats were randomly divided into two groups: diabetic group which was injected STZ (60 mg/kg BW), and a non-diabetic group. Three days after diabetes induction, each of these groups was randomly divided into 3 subgroups of 6 animals ((1) control, (2) 1%/food CLN, (3) 1%/food NCLN). The animals were supplemented for 28 days, starting three days after STZ administration. At the end of the study, blood was drawn for biochemical assays. The weights and FIs of the rats were measured at the beginning and end of each week.Results: Our findings revealed that there was no significant change in lipid profile, 28 days after administration of STZ in diabetic rats. Low density lipoprotein (LDL) was increased slightly in diabetic rats treated with NCLN without any significant changes in other lipid profile parameters in the other groups. Weight was reduced significantly in diabetic rats. Administration of CLN and NCLN prevented further weight loss in diabetic rats. All groups treated with STZ had higher food intake during the study.Conclusion: Lack of beneficial changes in lipid profile may be attributed to short study duration, insufficient for appearance of lipid abnormalities. Given the partial improvement in weight status and lack of undesirable effects of clinoptilolite supplementation, further research is recommended in subjects with typ1 diabetes mellitus.
Introduction: Breast cancer is the most common cancer in women and a global public health problem. Evidence shows that breast cancer may originate during early life. Although diet has been implicated as playing a major role in prevention of breast cancer, we do not know what dietary factors are responsible for initiating and developing breast cancer. The objective of this review was to assess a possible role of dietary fat intake in fetal and lactation in increases breast cancer risk in adulthood. Materials and Methods:This review includes a summary of original article and review in full text from 2000-2017 and was performed using pubmed, science direct, scopus, and google scholar databases for terms: breast cancer, diet, dietary fat, pregnancy, lactation, fetal, fatty acid, w3, w6. Results: According to our search 6 article, including 6 animal, 2 review was investigated the relationship between maternal fat intake and breast cancer risk in the female offspring. Intake of canola oil, w3 and fish oil delayed mammary gland tumor development in animal. results showed intake of a lard-based high-fat diet rich in SFA and fat n-6 polyunsaturated acid during pregnancy increases female offspring's mammary cancer risk, while a study suggest an exposure to a lard-based HF diet during early life changes the fatty acid profile and transcriptional network in mammary gland in young adult rats these changes appear to be consistent with reduced mammary cancer risk. Conclusions:The literature suggests that the breast cancer risk of offspring can be programmed by maternal dietary fat intake, but further researches are recommended.
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