The aim of this study was to evaluate the in vitro antioxidant and antimicrobial properties of the natural cyclic hydroxamic acid: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA). Antioxidant activity of the isolated DIMBOA was examined using DPPH, FRAP and ABTS tests. It was found that DIMBOA exhibits a potent free-radical scavenging activity and a weaker iron (III) ions reducing activity. Antimicrobial activity against selected G(+), G(-) bacterial strains and against yeasts-like reference strains of fungi was investigated using disk-diffusion method. It has been shown that DIMBOA possess growth inhibitory properties against many strains of studied bacteria and fungi, such as Staphylococcus aureus, Escherichia coli as well as against Saccharomyces cerevisiae.
The visual outcomes of vitrectomy in a series of five eyes of three patients with vitreous haemorrhage due to Terson syndrome were retrospectively evaluated. There were two bilateral cases and one unilateral. The neurological diagnosis included cranio-cerebral trauma and cerebral aneurysm rupture. The mean time interval between intracranial haemorrhage and vitrectomy was nine months (range 7-10 months). Pars plana vitrectomy was performed with BSS as a tamponade in three eyes, SF6 gas in one eye, and silicone oil in one eye. The mean follow-up period was 12 months (range 1-27 months). Visual acuity improved significantly in all patients from counting fingers to the mean value of 0.6 (range 0.1-1.0). We observed one epiretinal membrane, one tractional retinal detachment, and two cataract formations. The best visual outcomes were achieved with BSS as a tamponade, the worst was with silicone oil as a tamponade and retinal detachment. Performing vitrectomy with BSS as a tamponade in patients with Terson syndrome significantly improves visual acuity, so early diagnosis and surgical treatment are crucial.
We describe a case of a 37-year-old man who developed prolonged papilledema as a result of increased intracranial pressure following unilateral radical neck dissection due to diffuse large B-cell non-Hodgkin lymphoma. It seems that the increase in intracranial pressure was a result of insufficient collateral venous drainage of the brain. Clinical examination showed bilateral papilloedema, diplopia, and visual deterioration in the left eye. Magnetic resonance imaging and computed tomography of the brain were normal. Semi-automated kinetic perimetry was used to monitor the visual function during 12 months of the follow-up. This method revealed enlargement of the blind spot in the left eye without progression. Peripheral borders of the visual field were within normal limits.
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