Content Addressable Memories (CAMs) are considered a key-enabler for in-memory computing (IMC). IMC shows order of magnitude improvement in energy efficiency and throughput compared to traditional computing techniques. Recently, analog CAMs (aCAMs) were proposed as a means to improve storage density and energy efficiency. In this work, we propose two new aCAM cells to improve data encoding and robustness as compared to existing aCAM cells. We propose a methodology to choose the margin and interval width for data encoding. In addition, we perform a comprehensive comparison against prior work in terms of the number of intervals, noise sensitivity, dynamic range, energy, latency, area, and probability of failure.
DNA pattern matching is essential for many widely used bioinformatics applications. Disease diagnosis is one of these applications, since analyzing changes in DNA sequences can increase our understanding of possible genetic diseases. The remarkable growth in the size of DNA datasets has resulted in challenges in discovering DNA patterns efficiently in terms of run time and power consumption. In this paper, we propose an efficient hardware and software codesign that determines the chance of the occurrence of repeat-expansion diseases using DNA pattern matching. The proposed design parallelizes the DNA pattern matching task using associative memory realized with analog content-addressable memory and implements an algorithm that returns the maximum number of consecutive occurrences of a specific pattern within a DNA sequence. We fully implement all the required hardware circuits with PTM 45-nm technology, and we evaluate the proposed architecture on a practical human DNA dataset. The results show that our design is energy-efficient and significantly accelerates the DNA pattern matching task compared to previous approaches described in the literature.
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