Mushroom, a nutrient-dense versatile food can share some of the benefits of fruits and vegetable and complement almost any everyday meal. Mushroom cultivation also requires low technology, low investment and can be grown in very little space. Due to culinary, nutritional and health benefits, the mushroom market is expected to grow as "a food, a tonic and a medicine". In the study food value of mushroom was found comparatively higher than that of other vegetables, fruits, meat and fish. This discussion suggests that the potentiality of mushroom cultivation could be a possible offer to alternate food and develop the life style of the people.
We studied the effect of chronic oral exposure to lead acetate (PbA) on the sensitivity of RBC to hemolysis and whether the sensitivity could be decreased by feeding the rats with extract of medicinal mushroom Ganoderma lucidum. Three groups of rats, control, PbA-exposed, and G. lucidum (Gl)+PbA, were used. PbA (3 mM) was administered via drinking water and G. lucidum extract by gavage at 300 mg/Kg BW/day for 12 weeks. Afterwards, the rats were killed and washed RBCs were subjected to hemolysis in the presence of Fenton's reagents. Hemolysis was determined by estimating the amount of released hemoglobin. The levels of lipid peroxide (LPO) and GSH were determined from RBC membranes and whole RBCs, respectively. The levels of TNFα and LPO also were determined from hepatic tissues. The RBCs of PbA-exposed rats displayed significantly higher sensitivity to hemolysis than those of the Gl+PbA rats. The levels of LPO increased and GSH decreased in the RBCs, with concomitant increases in the levels of hepatic TNFα and LPO in the PbA-exposed rats. The degree of hemolysis was significantly low in the RBCs of Gl+PbA rats, concurrently with amelioration of hepatic parameters. Finally, the study suggests that PbA-induced-hemolysis and related oxidative-toxicity might be minimized by consumption of G. lucidum.
In the month of holy Ramadan, food habit of Bangladeshi Muslims grossly changed. During this period they prefer to take lots of oily fried items which might be the cause of hepatocellular injury. The study was undertaken to find out the effect of oyster mushroom (P. ostreatus) on the serum level of hepatocellular enzymes like Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST), which are the two common markers for liver function tests (LFTs). The feeding of 50 grams fresh fried oyster mushroom as ifter item in Ramadan fast significantly reduced the serum levels of AST and ALT in female subjects as compared to those with the control females. Findings of the study suggest that P. ostreatus may be hepatoprotective in females and hence the human subjects.
:To evaluate the effect of Ramadan fast on serum lipid profile status of men, the study was carried out in the National Mushroom Development and Extension Centre, Sobhanbag, Savar Dhaka in association with the Department of Pharmacy and Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka. The experiment was conducted before and after the Arabic month, Ramadan, when there occurs a change both in the pattern and timing of dietary intake. Findings of the study shows Ramadan fast significantly reduced serum Low Density Lipoprotein (LDL-C) (p = 0.011). A statistically non significant reduction of total Cholesterol (TC) (p = 0.340), small elevation of High Density Lipoprotein (HDL-C) (p = 0.252) and Triglyceride (TG) (p = 0.502) were also observed. Considering the findings of the study it was noticeable that one month Ramadan fast can improve lipid profile status of blood and hence able to improve atherosclerotic diseases which includes hypertension, ischemic heart disease and stroke.
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