Background: The tumor-to-tumor metastasis is exclusively rare finding, in which one malignant neoplasia metastasizes to another tumor of different origin. Case: The author describes an 68-year-old woman, who was found to have a solitary tumor in the right kidney, as well as multiple tumor nodules in the liver. She underwent a radical nephrectomy. A histology of lesion in the kidney revealed a conventional clear cell renal cell carcinoma (RCC) harbor ing multiple metastatic foci of another adenocarcinoma. At that time, there was not possible to reliably specify a primary source. Subsequently, a probatory excision of tumor lesion in the liver was also done. A microscopy confirmed an adenocarcinoma with a similar appearance as found in RCC. Due to unfavourable health condition, a paliative chemother apy could not be realized and the patient died shortly thereafter. A primary origin of adenocarcinoma remained unclear. Conclusion: A unique case of metastatic adenocarcinoma is described, that was initially dia gnosed as an incidental find ing within a clear cell RCC of the kidney. Such unexpected feature may represent a great dia gnostic challenge for both, pathologist and clinician. From a prognostic point of view, an evidence of intratumoral cancer metastasis within a primary RCC is usually an indicator of disseminated oncologic dis ease with a poor outcome.
The effect of Venalot, a combination of two benzo-pyrones, on canine experimental acute pancreatitis was examined. Activities of lymph and blood plasma enzymes, thoracic duct lymph flow, and morphological changes of the pancreas were compared with those of a control group of dogs. The drug was found to enhance the removal of amylase and trypsin via lymph from the gland and to decrease the elevation of plasma amylase and lactate dehydrogenase. When administered simultaneously with the induction of pancreatitis, benzo-pyrones were effective in the reduction of pancreatic edema and necroses.
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