Cushing's syndrome has been demonstrated in four of seven siblings with clinical manifestations appearing around puberty in three of the four siblings. The only other associated findings in these cases were short stature and disturbed carbohydrate metabolism. Adenomatous hyperplasia of the adrenal glands was demonstrated in 3 of the patients, and a virilizing adrenal carcinoma in the fourth sibling. The pathogenesis of the adrenocortical disorders in these siblings is discussed.
Six men with benign macro‐orchidism are described. There was no clinical evidence of endocrine or urologic disorder, and male sex characteristics were normal. Semen analysis data, previously unreported, and fertility of three of them indicate normal spermatogenesis. The findings suggest that some normal men may have unusually large testes. In these subjects, both seminiferous tubule and androgenic function were clinically normal.
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