Bilateral Macro‐Orchidism in Otherwise Normal Men

Padrón, Rubén S.; Hung, Santiago; Licea, Manuel; Pérez‐Plaza, Miriam; Arce, Bartolomé

doi:10.1111/j.1365-2605.1979.tb00032.x

Cited by 9 publications

(1 citation statement)

References 11 publications

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“…Patients with bilateral megalotestis had markedly higher sperm concentrations and total sperm counts than controls. Also, percentages of progressively motile and morphologically intact spermatozoa were higher in group M. Similar findings were previously reported in a smaller study of 6 patients with bilateral macroorchidism (Padron et al, 1979).…”

Section: Discussionsupporting

confidence: 91%

Endocrine and spermatological characteristics of 135 patients with bilateral megalotestis

Meschede¹,

Behre²,

Nieschlag³

2009

Andrologia

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Little is known about the biological and clinical significance of bilaterally enlarged testes (bilateral megalotestes or macroorchidism). We have investigated clinical, endocrine and spermatological characteristics of 135 andrological patients with a testicular volume of more than 25 ml bilaterally. 135 patients with normal testicular volumes served as controls. Subjects with bilateral megalotestis had higher sperm counts and better sperm morphology and motility than the controls. Levels of LH, FSH, prolactin, testosterone and estradiol were lower in the megalotestis group. This was statistically significant for LH and FSH. No testicular tumours were diagnosed in either group. We conclude that in most andrological patients with bilateral megalotestes fertility parameters are excellent despite the unusually low hormone levels found in a significant minority. No specific pathology underlying the large gonadal volume could be identified.

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Section: Discussionsupporting

confidence: 91%

Endocrine and spermatological characteristics of 135 patients with bilateral megalotestis

Meschede¹,

Behre²,

Nieschlag³

2009

Andrologia

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Significance of phenotypic and chromosomal abnormalities in X‐linked mental retardation (Martin‐Bell or Renpenning syndrome)

et al. 1980

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With the exception of macro-orchidism, three families with X-linked mental retardation showed diagnostic concordance of clinical features among the affected males. Since macro-orchidism was a variable feature among the otherwise identically affected males in one family, we question the existence of a separate entity of X-linked mental retardation characterized only be testicular enlargement. The X chromosome marker of Lubs was expressed, under the culture conditions of Sutherland, in lymphocytes of the affected males of two families, one with and the other without megalotestes. Two affected members of the third family, with megalotestes, did not show the marker. Telomeric structural changes similar to the mar(X) (qter) formation were found on certain autosomes, notably, chromosome 6 in some of the affected males, potential and obligate carrier females, and in both related and unrelated normal males. These autosomal markers appear to represent a nonspecific response to either in vivo or in vitro folate deficiency. Caution against premature introduction of this test for prenatal diagnosis, in the face of current ignorance regarding diagnostic specificity, is urged.

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