Despite use of surgical adjuvants, pelvic adhesions frequently develop following infertility surgery. Recently a resorbable biocompatible material, TC 7, has been designed to be used as a barrier to reduce adhesion formation. Reproducibly severe sidewall adhesions were only able to be created in one of six models tested. The model consisted of the following steps: excision of a full thickness 2 x 2-cm musculoperitoneal tissue mass, scraping of an adjacent 2-cm length of uterine horn, tamponading of all bleeding, and suturing (6-0 Vicryl) of normal tube and sidewall so as to directly approximate the traumatized tissues. Studies were conducted in 13 rabbits after creation of the bilateral sidewall and horn lesions, each serving as its own control. Choice of control and TC 7 sides was determined randomly. Adhesion formation was examined 2 weeks postoperatively. No residual material was noted at that time. Adhesion scores were the composite total of extent (0-4), type (0-4), and tenacity (0-3) of sidewall adhesions, and were significantly reduced on the TC 7 side as compared with the control side (mean 6.8 +/- 0.4 vs 9.0 +/- 0.3, median 6 vs 9, sign test P = 0.0032). No complications of use of the barrier were noted. It is concluded that use of TC 7, a resorbable biocompatible barrier, was able to significantly reduce postoperative adhesion formation on the rabbit sidewall.
Guinea pig ear stratum corneum was removed to increasing depths by 1, 3, 6 or 9 strippings with adhesive tape. Increasing ornithine decarboxylase (ODC) activity responses were observed in the epidermis 4.5 hr after wounding with 3, 6 or 9 tape strippings. The kinetics of this ODC response were investigated at intervals including, 2, 4.5, 12, 18, 24 and 72 hr after tape stripping. ODC activity was significantly elevated for 12 hr after 3 or 6 tape strippings and for at least 72 hr after 9 tape strippings. These effects were independent of hair plucking or depilation prior to wounding. This model is potentially useful for comparing the effects of chemical, mechanical and physical stimuli on ODC activity and subsequent polyamine synthesis.
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