Diabetic retinopathy (DR), a common long-term neurovascular complication of diabetes mellitus (DM) with a major impact on quality of life, is one of the leading causes of visual impairment worldwide. 1-3 Although the vascular component of its pathogenesis is undisputable, the importance of neurodegenerative and inflammatory processes in the retina has emerged only recently. 4 The functionality of the neurovascular unit and the integrity of the blood-retina barrier depend on the function and communication of neural, glial, and vascular cells. Alterations of the neurovascular unit seem to precede the subclinical functional and morphological abnormalities. 5-7 Although much remains to be explored about the primary pathogenesis of DR, hyperglycemia is undoubtedly the initial in the

No abstract

This report proves the successful initiation of pancreatic islet transplantation in a center with a well-established PTx program. ITx has been shown to be the method of choice for hypoglycemia unawareness syndrome, and may be considered for application in clinical practice if conservative options are exhausted.

No abstract

No abstract