Interleukin 12 plays an important role in immunoregulation between the T helper 1/T helper 2 lymphocytes and in the antiviral and antitumor immune response. The aim of this study was to investigate the possible association between the interleukin 12B polymorphism rs3212227 and the risk to develop Hodgkin’s lymphoma in childhood and adolescents. A total of 100 patients with Hodgkin’s lymphoma and a group of 181 healthy controls were selected at random from a forensic laboratory of the University of Pernambuco. The AA genotype was detected in the controls (53.04%) and the AC genotype was found in the patients (54%). The AC genotype showed an association with the development of Hodgkin’s lymphoma (odds ratio = 2.091, 95% confidence interval = 1.240–3.523, p = 0.007). When AC + CC genotypes were analyzed together, an increase in risk of 1.9 times more chances for HL development could be observed (odds ratio = 1.923, 95% confidence interval = 1.166–3.170, p = 0.014). However, there was no association between the AC and CC genotypes of the interleukin 12B polymorphism with the clinical risk group (p = 0.992, p = 0.648, respectively). Our results suggest that the presence of the C allele may be contributing to the development of Hodgkin’s lymphoma in children and adolescents.
The study of Externally Visible Characteristics (EVC) of pigmentation associated with SNPs (Single Nucleotide Polymorphisms) has become a target in the forensic field due to the possibility of phenotypically characterizing an individual. In Brazil, there are few data that shows the evaluation of some these markers, so further studies are necessary to understand better the pigmentation process related to genetic markers. The aim of this study was to test the association between 8 SNPs present in HIrisplex tool and EVC to provide a starting point for the development of prediction models for heterogeneous populations like the one in Pernambuco. Were evaluated 176 individuals by associations between self-reported eye, hair and skin color data and polymorphisms. Artificial intelligence tools were used for the prediction models. Significant associations were found between rs1800404 (OCA2), rs6058017 (ASIP), rs16891982 (SLC45A2) and rs1426654 (SLC24A5) with (EVC). The prediction models evaluated showed satisfactory prediction rates, rates above 60% for skin color and above 70% for eyes and hair. The associations found in our data show the importance of SNPs evaluation used in DNA Phenotyping, because of its ability to provide new information in the context of criminal investigations. Our data indicate that is possible to use molecular information to predict phenotypes in miscigenated populations, like the Brazilian population. These polymorphisms could be possible phenotypic predictors for the Pernambuco population.
A vitamina D tem um importante papel na imunidade e sua deficiência ou insuficiência (hipovitaminose D) pode estar relacionada com o aumento da prevalência das doenças autoimunes. Em um estudo de coorte retrospectivo com amostras simples, advindas de um banco de dados hospitalar público, foi verificado o perfil de vitamina D de uma população. Participaram da pesquisa 2.977 pacientes de 127 municípios de Pernambuco, Brasil. Em 12,6% dos municípios foram encontradas médias normais de vitamina D (D≥30ng/ml) e em 87,4% hipovitaminose D (concentração sérica de D <30ng/mL). Recife expôs o maior número de habitantes com deficiência de vitamina D (321) e apresentou 100% da amostra feminina (n=650) com hipovitaminose D (D<30ng/ml). A deficiência de vitamina D (D≤20ng/mL) neste município foi identificada em 20,3% da amostra e a insuficiência (D≥20ng/mL<30ng/mL) em 79,7%. Nas cidades circunvizinhas a Recife, a média de deficiência de vitamina D foi 13,3% e a de insuficiência 86,7%. Com relação ao envolvimento da hipovitaminose D com doenças autoimunes, os artigos do estudo ressaltaram a associação da hipovitaminose D com o risco de doenças autoimunes. Quanto à prevalência da hipovitaminose D nas doenças autoimunes, 93,0% dos artigos concordaram com esta associação. Sobre a influência da hipovitaminose D na atividade da doença autoimune, 63,6% reconheceram esta associação. A predominância da hipovitaminose D está se agravando, principalmente, na população feminina e sem distinção de
As a result of its broad clinical presentation – from asymptomatic infection
to severe acute respiratory syndrome (SARS), COVID-19 has emerged as a
broadcasting pandemic worldwide. A viral test tells you if you have a current infection.
Confirmation of a high-risk for COVID-19 patient has been prioritized in containment
efforts. The current diagnostic methods for COVID-19 rely on higher sensitivity,
specificity, and faster results. Two types of diagnostic methods have been considered:
nucleic acid amplification tests and serological tests. Whereas the first one confirms
infection, the second might disclose outcomes from past infection or immunological
parameters left by the contamination. Here we collect emerging understanding of the
underlying role of molecular and serological tests incorporated in the routine of
COVID-19 diagnosis and outline some features related to the methodologies.
Objective: to understand the implications of widowhood on health, relating the life story of the couple, the time of union and the degree of affection to the type and severity of the pathology developed. Methodology: the study is descriptive with qualitative approach. The subjects include the least 10 elderly aged less than 60 years in case of widowhood, and without distinction of color, focusing on the appearance of disease in the period after loss of spouse. The scenario will be the Institute of Gerontological Education in the Municipality of Niterói/RJ. The technique chosen is the self-report and the instrument is the guide for semi structured interview. After data collection and transcription of the speech will be held the stage of defining the data, looking up the units of meaning to be examined in light of the theoretical referential Merleau-pontyan. Expected results: articulating the results, it expects to broaden the knowledge concerning the care of nursing in this context from the reference Merleau-pontyan. Descriptors: widowhood; nursing; psychosomatic.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.