Objectives To screen and verify differential genes affecting the prognosis of breast cancer. Methods Breast cancer gene expression datasets were downloaded from the GEO database, and original data were analyzed in R. The TIMER database was used to analyze the relationship between ANLN and UBE2T and immune cell infiltration. Results Ten hub-key genes were identified, and survival analysis showed that UBE2T and ANLN were upregulated in breast cancer and their upregulation was associated with a poor prognosis. ANLN and UBE2T upregulation was associated with the prevalence of Th1 and Th2 cells, shifting the Th1/Th2 balance to Th2 in Basal and Luminal-B breast cancers, which indicates a poor prognosis (P < 0.05). Conclusion ANLN and UBE2T are potential biomarkers for predicting the prognosis of breast cancer.
Silicon carbide (SiC) was modified by melamine polyphosphate (MPP)-modified silicone to form SiC-MPP, then incorporated into epoxy resin (EP) for developing thermally resistant composites, which showed thermal conductivity and flame retardancy performance. The EP/SiC-MPP composites were prepared by blending and cured under 60°C for 2 h and 150°C for 8 h. The grafting degree of SiC-MPP was analyzed using Fourier transform Infrared, scanning electron microscope, and thermogravimetric measurements. The flame retardancy of the EP/SiC-MPP composites was studied by UL-94 vertical combustion and cone calorimetry test. The results showed that for EP/SiC-MPP containing 20 wt%, the UL-94 was case V1. Also compared to pure epoxy, the peak heat release rate (PHRR) of composites was reduced from 800 to 304 kW·m−2. The thermal conductivity of EP/SiC-M20 composites was 0.53 W·m−1·K−1, almost 2.5-fold higher than pure epoxy (0.21 W·m−1·K−1). The as-prepared EP/SiC-MPP composites exhibited enhanced flame retardancy and thermal conductivity. Based on analyses performed, these composites took credit-related applications.
Surface chemical modification of boron nitride could enhance the compatibility with polymers and improve flame retardancy performances. In this work, the double‐bond active sites were constructed on the surface of boron nitride modified by the γ‐methacryloyloxypropyl trimethoxysilane (KH570). Glycidyl methacrylate (GMA) was further grafted onto the surface of boron nitride via free radical polymerization. Finally, the flame retardancy melamine polyphosphate (MPP) was bonded to the surface of boron nitride by the ring opening reaction. This modification process was proved to be achieved by infrared spectroscopy and thermogravimetric test. The boron nitride modified by flame retardant were added into the epoxy matrix and cured to prepare flame retardant and thermal conductive composites. The flame retardant of the composites was studied by cone calorimetry, UL94 vertical combustion test and limiting oxygen index. The thermal conductivity of the composites was characterized by laser thermal conductivity instrument. The results showed that when the addition amount of flame retardancy MPP modified boron nitride in the composites was 20 wt%, the flame retardant rating of UL94 reached to V1; the limiting oxygen index was increased from 25.1 vol% of pure epoxy resin to 30.3 vol%; the PHRR of pure epoxy resin was reduced from 800 to 510 kW/m2 of composites; the thermal conductivity of the composites was enhanced from 0.21 W/m•K−1 of the pure epoxy resin to 0.82 W/m•K−1of the composites.
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