ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis

Abstract

Objectives To screen and verify differential genes affecting the prognosis of breast cancer. Methods Breast cancer gene expression datasets were downloaded from the GEO database, and original data were analyzed in R. The TIMER database was used to analyze the relationship between ANLN and UBE2T and immune cell infiltration. Results Ten hub-key genes were identified, and survival analysis showed that UBE2T and ANLN were upregulated in breast cancer and their upregulation was associated with a poor prognosis. ANLN and UBE2T upregulation was associated with the prevalence of Th1 and Th2 cells, shifting the Th1/Th2 balance to Th2 in Basal and Luminal-B breast cancers, which indicates a poor prognosis (P < 0.05). Conclusion ANLN and UBE2T are potential biomarkers for predicting the prognosis of breast cancer.

Identification of MIR600HG/hsa-miR-342-3p/ANLN network as a potential prognosis biomarker associated with lmmune infiltrates in pancreatic cancer

“…We construct a risk score containing ANLN, previous studies 19 , 20 have found that the expression of ANLN is closely related to immune infiltration, so we explored whether the risk score containing ANLN can affect immune infiltration of pancreatic cancer. We performed ssGSEA to calculate the immune infiltration score of 24 immune cells in each sample, and the Cox proportional hazard regression method was used to evaluate the relationship between the infiltration of 24 types of immune cells and survival.…”

Differential whole-genome doubling based signatures for improvement on clinical outcomes and drug response in patients with breast cancer

“…ANLN upregulation has been observed in 21 types of cancers and has been associated with poor OS, DFI, and PFI in most cancers [ 76 ]. Multiple studies have proposed ANLN as a potential molecular marker for predicting breast cancer diagnosis [ 59 , 77 ]. Additionally, ANLN has been recognized as a crucial regulatory factor involved in various signaling events, particularly those related to the cell cycle and nucleocytoplasmic transport pathways [ 78 ].…”

Weighted Gene Co-Expression Network Analysis Based on Stimulation by Lipopolysaccharides and Polyinosinic:polycytidylic Acid Provides a Core Set of Genes for Understanding Hemolymph Immune Response Mechanisms of Amphioctopus fangsiao

“…Its importance extends to participation in the PI3K/PTEN signaling pathway, crucial in cellular life-death control [ 66 , 67 ]. Additionally, ANLN ’s interaction with multiple immune cells underscores its indispensable role in the immune system [ 68 , 69 ]. Meanwhile, Interferon regulatory factor 2 (IRF2), a family member of the transcriptional factors, plays an instrumental role in modulating IFN-induced immune responses [ 70 ].…”