The Salvia miltiorrhiza and Panax notoginseng herb pair (DQ) has been widely
utilized in traditional Chinese medicine for the longevity and for
preventing and treating cardio-cerebrovascular diseases. Often associated
with cardio-cerebrovascular diseases are comorbidities such as insulin
resistance. However, the protective mechanisms of DQ against insulin
resistance remain not well understood. Through network pharmacology
analysis, a total of 94 candidate active compounds selected from DQ
(61 from S. miltiorrhiza Bunge and
33 from P. notoginseng (Burk.) F. H.
Chen) interacted with 52 corresponding insulin resistance-related
targets, which mainly involved insulin resistance and the AMPK signaling
pathway. Furthermore, the contribution index calculation results indicated
25 compounds as the principal components of this herb pair against
insulin resistance. Among them, ginsenoside F2, protocatechuic acid,
and salvianolic acid B were selected and validated to promote glucose
consumption through activating AMPK phosphorylation and upregulating
GLUT4 in insulin-resistant cell model (HepG2/IR) cells. These findings
indicated that DQ has the potential for repositioning in the treatment
of insulin resistance mainly through the AMPK signaling pathway.
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