How to cite this article Panahande B., Sadeghi A., Parohan M. (2019) Alternative healthy eating index and risk of hip fracture: a systematic review and dose-response meta-analysis. J Hum Nutr Diet. 32, 98-107 https://doi.
AbstractBackground: A high adherence to healthy dietary patterns, such as an alternative healthy eating index (AHEI), has been suggested to have protective effects on bone mineral density and to decrease the incidence of fractures, although the evidence for this is not clear. We conducted a dose-response meta-analysis of available observational studies aiming to assess the association between adherence to a healthy dietary pattern, as assessed by the AHEI score, and risk of hip fracture in the general population. Methods: Studies published up to March 2018 were identified on the basis of a literature search in PubMed, Scopus and ISI Web of Science databases using Mesh and non-Mesh relevant keywords. Relative risks (RRs) with 95% confidence intervals (CIs), the linear and nonlinear relationships were calculated using random-effects models. Results: In the meta-analysis of five effect sizes, as obtained from four studies (265 771 participants with 6938 cases of incident hip fracture), we found that a higher AHEI score was associated with a 31% reduced risk of hip fracture (pooled RR = 0.69; 95% CI = 0.52-0.91) in high versus low intake meta-analysis. In addition, there were inverse relationships between AHEI score and risk of hip fracture, such that a five-unit increase in the score of AHEI was associated with a reduction in the risk of hip fracture in linear (pooled RR = 0.97; 95% CI = 0.95-0.99) and nonlinear (Pnonlinearity < 0.001) models, respectively. Conclusions: Adherence to the AHEI (as an indicator of diet quality) was associated with a reduced risk of hip fracture.
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Background: The role of coffee consumption in the risk of cardiovascular diseases has been debated for many years. The current study aimed to summarize earlier evidence on the effects of green coffee extract (GCE) supplementation on glycemic indices and lipid profile. Methods: We searched available online databases for relevant clinical trials published up to October 2019. All clinical trials investigating the effect of GCE supplementation, compared with a control group, on fasting blood glucose (FBG), serum insulin, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were included. Overall, 14 clinical trials with a total sample size of 766 participants were included in the current meta-analysis. Results: We found a significant reducing effect of GCE supplementation on FBG (weighted mean difference (WMD):-2.35, 95% CI: − 3.78, − 0.92 mg/dL, P = 0.001) and serum insulin (WMD:-0.63, 95% CI: − 1.11, − 0.15 μU/L, P = 0.01). With regard to lipid profile, we observed a significant reduction only in serum levels of TC following GCE supplementation in the overall meta-analysis (WMD:-4.51, 95% CI: − 8.39, − 0.64, P = 0.02). However, subgroup analysis showed a significant reduction in serum TG in studies enrolled both genders. Also, such a significant reduction was seen in serum levels of LDL and HDL when the analyses confined to studies with intervention duration of ≥8 weeks and those included female subjects. In the non-linear dose-response analyses, we found that the effects of chlorogenic acid (CGA) dosage, the main polyphenol in GCE, on FBG, TG and HDL were in the nonlinear fashions.
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