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The results of this study demonstrated that increased thoracic kyphosis negatively affects gait performance and quality of life. This finding could be regarded as an important implication for therapist to pay more attention to the magnitude of thoracic kyphosis angle and its changes, when selecting appropriate therapeutic methods to improve gait performance and quality of life in osteoporosis women.

Purpose: Few studies have summarized findings for the effect of metformin on obesity indices. Therefore, we aimed to conduct a systematic review and meta-analysis on the effect of metformin on obesity indices among children and adolescents.Methods: Relevant articles published up to September 2018 were searched in SCOPUS, Medline, and Google Scholar using appropriate keywords. All clinical trials that examined the effect of metformin on obesity indices in children and adolescents were included.Results: Overall, 38 studies, including 2199 participants (39.75% male and 60.25% female), were included. The pooled results indicated that metformin significantly reduced BMI [weighted mean difference (WMD): -1.07 kg/m 2 ; 95% confidence interval (CI): -1.43 to -0.72]. Same findings were found for waist circumference (WC) (WMD: -1.93 cm; 95% CI: -2.69 to -1.16). Metformin also reduced body weight in all participants (WMD: -2.51 kg; 95% CI: -3.14 to -1.89). Moreover, it reduced body fat mass in patients with overweight or obesity (WMD: -1.90%; 95% CI: -3.25 to -0.56) and chronic diseases (WMD: -1.41%; 95% CI: -2.23 to -0.58), but not among those with growth problems. Metformin therapy did not affect lean body mass (LBM) in patients with overweight or obesity and growth problems; however, it reduced LBM in patients with chronic diseases (WMD: -1.49 kg; 95% CI: -2.69 to -0.30).Conclusions: We found a significant reduction in BMI, body weight, WC, and fat mass following administration with metformin. However, the effect of metformin on LBM was not significant. Further studies are required to confirm these findings.

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Purpose: The purpose of this study was to compare the efficacy and safety of a proposed bevacizumab biosimilar to those of the reference product in patients with metastatic colorectal cancer (mCRC).Methods: This Phase III, multicenter, randomized, double-blind (patient-and assessor-blind), activecontrolled, 2-armed, parallel-group, noninferiority trial was conducted in patients with histologically verified colorectal cancer with evidence of at least 1 metastasis. Patients with mCRC were randomized 2:1 to receive 5 mg/kg IV of either study drug plus FOLFIRI-3 (with repeated irinotecan 100 mg/m 2 60-min infusion on day 3) or the reference drug plus FOLFIRI-3 every 2 weeks for 1 year. Progression-free survival (PFS) was the primary end point, and overall survival, objective response rate, and time to treatment failure as well as safety and immunogenicity were secondary end points. The population assessable for PFS was per protocol, and

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How to cite this article Panahande B., Sadeghi A., Parohan M. (2019) Alternative healthy eating index and risk of hip fracture: a systematic review and dose-response meta-analysis. J Hum Nutr Diet. 32, 98-107 https://doi. AbstractBackground: A high adherence to healthy dietary patterns, such as an alternative healthy eating index (AHEI), has been suggested to have protective effects on bone mineral density and to decrease the incidence of fractures, although the evidence for this is not clear. We conducted a dose-response meta-analysis of available observational studies aiming to assess the association between adherence to a healthy dietary pattern, as assessed by the AHEI score, and risk of hip fracture in the general population. Methods: Studies published up to March 2018 were identified on the basis of a literature search in PubMed, Scopus and ISI Web of Science databases using Mesh and non-Mesh relevant keywords. Relative risks (RRs) with 95% confidence intervals (CIs), the linear and nonlinear relationships were calculated using random-effects models. Results: In the meta-analysis of five effect sizes, as obtained from four studies (265 771 participants with 6938 cases of incident hip fracture), we found that a higher AHEI score was associated with a 31% reduced risk of hip fracture (pooled RR = 0.69; 95% CI = 0.52-0.91) in high versus low intake meta-analysis. In addition, there were inverse relationships between AHEI score and risk of hip fracture, such that a five-unit increase in the score of AHEI was associated with a reduction in the risk of hip fracture in linear (pooled RR = 0.97; 95% CI = 0.95-0.99) and nonlinear (Pnonlinearity < 0.001) models, respectively. Conclusions: Adherence to the AHEI (as an indicator of diet quality) was associated with a reduced risk of hip fracture. 98