Sepsis is defined as life -threatening organ dysfunction due to dysregulated host response to infection. Mortality due to sepsis is more than 30%. Early identification and early goal directed therapy in sepsis are important for good outcome. Here in this study we are trying to assess the thyroid function test and its association with clinical outcome in sepsis patients. The objective is to assess the thyroid function test among the patients presenting with sepsis. This is a Prospective study that included 70 patients admitted in Chettinad Hospital And Research Institute with sepsis.Low FT3 levels correlated significantly with the primary outcome with a cut off value of <1.13pg/ml. All the three thyroid function test (FT3, FT4, TSH) had a significant correlation with the primary and secondary outcome in subjects with sepsis. Low FT3 levels can be considered as a single independent predictive mortality marker in subjects with sepsis. Raised TSH levels can be considered as a predictive marker for requirement of ionotropic support in subjects with sepsis. In patients with Low FT4 Levels interventional procedure requirement is high.
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