Lymphomas are a heterogeneous group of disorders arising from constituent cells of the immune system. The SUVmax (standardised uptake value) on PET/CT reects the tumor's aggressiveness. In this study, we observe the SUVmax in FDG-PET/CT and correlate it with the histopathological diagnosis and proliferation index in various grades of non-Hodgkin lymphoma (NHL). 187 cases of NHLs received at the Department of Pathology during the years 2018–2020 were included in the study. The age, nal histopathological diagnosis, Ki67 index, and SUVmax for each case were collected. Statistical analysis was performed using SPSS 23 to establish a correlation between histopathological diagnosis, the Ki67 index, and the SUVmax. There was a signicant correlation between high-grade lymphomas and SUVmax (r = 0.416, P value 0.001) and also between SUV max and the KI67 proliferation index (r = 0.731, Pvalue 0.001). The sensitivity and specicity of SUVmax were 70% and 76%, respectively. There is an acceptable correlation between the nal histopathological diagnosis, SUVmax, and Ki67, thus suggesting that SUVmax can be used as an additional tool for the early detection of high-grade lymphomas, rapid transformation, and recurrence in a known case
Multicystic dysplastic kidney (MCDK) is the most common form of developmental abnormality seen in infants and children. It is almost always unilateral and slightly more frequent in boys and on the left side. The other associated extra-renal abnormalities include esophageal atresia, tracheoesophageal atresia, ventricular septal defect and patent ductus arteriosus. The routine widespread use of antenatal ultrasonography has led to early detection of this abnormality. Materials and Methods: We retrospectively assessed fourteen cases of Multicystic dysplastic kidney between January 2004 and December 2014. All the cases underwent total nephrectomy and the specimens were sent to the department of Pathology with their respective clinical details and pathological findings were analyzed. Results: A total of fourteen ( 14) patients were diagnosed with unilateral MCDK over a period of 10 years with no sex predilection. Majority were on left side and antenatally diagnosed. Some patients had associated hypertension, vesicoureteral reflux and ureteropelvic junction obstruction. Microscopy revealed renal parenchyma replaced by cysts of variable sizes lined by flattened cuboidal epithelium. Intervening fibrotic stroma with mesenchymal components, primitive glomeruli, nerve bundles and dysplastic ducts. Conclusion: MCDK is mostly a unilateral sporadic anomaly usually found on the left side, however can be familial. It may be associated with hypertension, vesicoureteral reflux and ureteropelvic junction obstruction. Most of the patients can be diagnosed antenatally and confirmed on histopathology.
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