A Correlational Study of Histopathology and FDG-Pet/Ct in the Diagnosis of Various Grades of Non-Hodgkin Lymphomas.

Abstract

Lymphomas are a heterogeneous group of disorders arising from constituent cells of the immune system. The SUVmax (standardised uptake value) on PET/CT reects the tumor's aggressiveness. In this study, we observe the SUVmax in FDG-PET/CT and correlate it with the histopathological diagnosis and proliferation index in various grades of non-Hodgkin lymphoma (NHL). 187 cases of NHLs received at the Department of Pathology during the years 2018–2020 were included in the study. The age, nal histopathological diagnosis, Ki67 index, and SUVmax for each case were collected. Statistical analysis was performed using SPSS 23 to establish a correlation between histopathological diagnosis, the Ki67 index, and the SUVmax. There was a signicant correlation between high-grade lymphomas and SUVmax (r = 0.416, P value 0.001) and also between SUV max and the KI67 proliferation index (r = 0.731, Pvalue 0.001). The sensitivity and specicity of SUVmax were 70% and 76%, respectively. There is an acceptable correlation between the nal histopathological diagnosis, SUVmax, and Ki67, thus suggesting that SUVmax can be used as an additional tool for the early detection of high-grade lymphomas, rapid transformation, and recurrence in a known case